Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31414959 | 1.00 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2TSHRLMNA | |
| SCHEMBL23406055 | 0.86 | SMN1; SMN2 (0.65) | RAB9ANPC1SMN1; SMN2LMNAHIF1A | |
| SCHEMBL6642201 | 0.85 | KMT2A (0.67) | RAB9ANPC1SMN1; SMN2TSHRLMNA | |
| SCHEMBL3408514 | 0.85 | RAB9A (0.72) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL997866 | 0.84 | RAB9A (0.89) | RAB9ANPC1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL29366822 | 0.84 | RAB9A (0.89) | RAB9ANPC1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL5359661 | 0.84 | GAA (0.66) | RAB9ANPC1SMN1; SMN2TSHRLMNA | |
| SCHEMBL7189774 | 0.83 | RAB9A (0.86) | RAB9ANPC1SMN1; SMN2LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL27681799 | 0.83 | RAB9A (0.86) | RAB9ANPC1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL23406080 | 0.83 | SMN1; SMN2 (0.58) | RAB9ANPC1SMN1; SMN2LMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016102969-A1 | INHIBITION OF HAIR GROWTH | THE UNIVERSITY OF MANCHESTER (GB) | 2016-06-30 | — | — | WO | claimed |
| EP-1453831-A1 | 1H-PYRROLO(3,2-B)PYRIDINE-3-CARBOXYLIC ACID AMIDES | Neurogen Corporation (US) | 2004-09-08 | — | — | EP | claimed |
| WO-2003044018-A1 | 1H-PYRROLO[3,2-B]PYRIDINE-3-CARBOXYLIC ACID AMIDES | NEUROGEN CORPORATION (US) | 2003-05-30 | — | — | WO | claimed |
| JP-57131719-A | — | — | None | — | — | JP | disclosed |
| WO-2016102969-A1 | INHIBITION OF HAIR GROWTH | THE UNIVERSITY OF MANCHESTER (GB) | 2016-06-30 | — | — | WO | disclosed |
| WO-2013059582-A2 | SMALL MOLECULE INHIBITORS OF HISTONE DEACTEYLASES | NUPOTENTIAL, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| EP-1453831-A1 | 1H-PYRROLO(3,2-B)PYRIDINE-3-CARBOXYLIC ACID AMIDES | Neurogen Corporation (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003044018-A1 | 1H-PYRROLO[3,2-B]PYRIDINE-3-CARBOXYLIC ACID AMIDES | NEUROGEN CORPORATION (US) | 2003-05-30 | — | — | WO | disclosed |
| EP-0083378-A1 | Tetrahydronicotinamide derivatives, a process for producing the same and a pharmaceutical composition comprising the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1983-07-13 | — | — | EP | disclosed |
| US-4361572-A | Tetrahydronicotinamide derivative, pharmaceutical compositions and use | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-11-30 | — | — | US | disclosed |
| JP-S57131719-A | BLOOD SUGAR LEVEL LOWERING AGENT | CHUGAI PHARMACEUT CO LTD | 1982-08-14 | — | — | JP | disclosed |