Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401769 | 0.92 | EGFR (0.41) | EGFRFGFR1KDRUTS2RLMNA | |
| SCHEMBL3406619 | 0.90 | EGFR (0.38) | EGFRFGFR1KDRUTS2RLMNA | |
| SCHEMBL976498 | 0.90 | EGFR (0.38) | EGFRFGFR1KDRUTS2RLMNA | |
| SCHEMBL3403104 | 0.90 | EGFR (0.39) | EGFRFGFR1KDRUTS2RNPC1 | |
| SCHEMBL976524 | 0.88 | EGFR (0.40) | EGFRFGFR1KDRUTS2RLMNA | |
| SCHEMBL976523 | 0.88 | EGFR (0.40) | EGFRFGFR1KDRUTS2RLMNA | |
| SCHEMBL3408673 | 0.87 | DRD2 (0.40) | EGFRFGFR1KDRLMNATP53 | |
| SCHEMBL3406077 | 0.87 | PRMT5 (0.43) | EGFRFGFR1KDRALDH1A1 | |
| SCHEMBL977764 | 0.87 | CCR2 (0.40) | EGFRFGFR1KDRUTS2RF10 | |
| SCHEMBL976516 | 0.87 | EGFR (0.40) | EGFRFGFR1KDRUTS2RF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254862-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | Sanofi-Aventis (FR) | 2010-12-01 | — | — | EP | claimed |
| WO-2009118473-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2009-10-01 | — | — | WO | claimed |