⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19716242 | 0.97 | CA2 (0.36) | — | |
| SCHEMBL28849785 | 0.78 | — | — | |
| SCHEMBL15129698 | 0.77 | CA2 (0.35) | — | |
| SCHEMBL28438646 | 0.74 | — | — | |
| Phosphonic Acid SCHEMBL5482535 | 0.71 | — | — | |
| SCHEMBL23531715 | 0.71 | ALDH1A1 (0.35) | — | |
| SCHEMBL29133667 | 0.71 | ALDH1A1 (0.35) | — | |
| SCHEMBL15904389 | 0.71 | ALDH1A1 (0.35) | — | |
| Methylpiperazine SCHEMBL28969663 | 0.70 | PHGDH (0.38) | — | |
| Piperazine SCHEMBL1483972 | 0.68 | HIF1A (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11976279-B2 | Methods and compositions for managing vascular conditions using miR-483 mimics and HIF1alpha pathway inhibitors | EMORY UNIVERSITY (US) | 2024-05-07 | — | — | US | claimed |
| US-20220090079-A1 | Methods and Compositions for Managing Vascular Conditions Using miR-483 Mimics and HIF1alpha Pathway Inhibitors | UNIV EMORY (US) | 2022-03-24 | — | — | US | claimed |
| US-11149274-B2 | Methods and compositions for managing vascular conditions | EMORY UNIVERSITY (US) | 2021-10-19 | — | — | US | claimed |
| US-20200095583-A1 | Methods and Compositions for Managing Vascular Conditions | UNIV EMORY (US) | 2020-03-26 | — | — | US | claimed |
| US-20190112603-A1 | Methods and Compositions for Managing Vascular Conditions Using miR-483 Mimics and HIF1alpha Pathway Inhibitors | UNIV EMORY (US) | 2019-04-18 | — | — | US | claimed |
| US-20180362984-A1 | Methods and Compositions for Managing Vascular Conditions | UNIV EMORY (US) | 2018-12-20 | — | — | US | claimed |
| US-9932585-B2 | Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto | EMORY UNIVERSITY (US) | 2018-04-03 | — | — | US | claimed |
| US-20170051284-A1 | Manipulating MicroRNA for the Management of Neurological Diseases or Conditions and Compositions Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-02-23 | — | — | US | claimed |
| US-9458458-B2 | Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto | EMORY UNIVERSITY (US) | 2016-10-04 | — | — | US | claimed |
| US-20160002628-A1 | METHODS AND COMPOSITIONS FOR MANAGING VASCULAR CONDITIONS | EMORY UNIVERSITY | 2016-01-07 | — | — | US | claimed |
| US-20150133522-A1 | MANIPULATING MICRORNA FOR THE MANAGEMENT OF NEUROLOGICAL DISEASES OR CONDITIONS AND COMPOSITIONS RELATED THERETO | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-14 | — | — | US | claimed |
| US-20140309280-A1 | ASSAYS FOR MICRO-RNA-182 AS A BIOMARKER FOR MUSCLE ATROPHY AND THERAPEUTIC APPLICATIONS | EMORY UNIVERSITY (US) | 2014-10-16 | — | — | US | claimed |
| WO-2014164753-A1 | METHODS AND COMPOSITIONS FOR MANAGING VASCULAR CONDITIONS | EMORY UNIVERSITY (US) | 2014-10-09 | — | — | WO | claimed |
| EP-4392558-A1 | ANTISENSE OLIGONUCLEOTIDES HAVING ONE OR MORE ABASIC UNITS | Sarepta Therapeutics, Inc. (US) | 2024-07-03 | — | — | EP | disclosed |
| EP-4387676-A2 | DELIVERY OF ANITSENSE OLIGOMERS BY MIRROR IMAGE PEPTIDES | Sarepta Therapeutics, Inc. (US) | 2024-06-26 | — | — | EP | disclosed |
| US-11976279-B2 | Methods and compositions for managing vascular conditions using miR-483 mimics and HIF1alpha pathway inhibitors | EMORY UNIVERSITY (US) | 2024-05-07 | — | — | US | disclosed |
| EP-2132284-A2 | ADDITIVE FORMULATION SUITED FOR ANTI-STATIC FINISHING AND IMPROVEMENT OF THE ELECTRICAL CONDUCTIVITY OF INANIMATE ORGANIC MATERIAL | BASF SE (DE) | 2009-12-16 | — | — | EP | disclosed |
| CN-100475824-C | Novel phosphonic acid compounds as inhibitors of serine proteases | ORTHO MCNEIL PHARM INC (US) | 2009-04-08 | — | — | CN | disclosed |
| WO-2008107371-A2 | ADDITIVE FORMULATION SUITED FOR ANTI-STATIC FINISHING AND IMPROVEMENT OF THE ELECTRICAL CONDUCTIVITY OF INANIMATE ORGANIC MATERIAL | BASF SE (DE) | 2008-09-12 | — | — | WO | disclosed |
| CN-1832950-A | Novel phosphonic acid compounds as inhibitors of serine proteases | ORTHO MCNEIL PHARM INC (US) | 2006-09-13 | — | — | CN | disclosed |