Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410480 | 0.86 | MEN1 (0.48) | KMT2AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3412729 | 0.85 | SYK (0.40) | KMT2AKDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3410261 | 0.83 | SYK (0.37) | KMT2AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3406529 | 0.83 | MEN1 (0.41) | KMT2AKDM4EGAAHPGDSMN1; SMN2 | |
| SCHEMBL3406645 | 0.83 | SMN1; SMN2 (0.37) | KMT2AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3409867 | 0.82 | MEN1 (0.41) | KMT2AKDM4EGAAHPGDSMN1; SMN2 | |
| SCHEMBL3409991 | 0.82 | KMT2A (0.39) | KMT2AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3412371 | 0.82 | MEN1 (0.40) | KMT2AKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3412246 | 0.81 | SYK (0.42) | KMT2AKDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4096394 | 0.80 | PSEN1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |