Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5369633 | 0.75 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1MAPK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5369625 | 0.74 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL7695939 | 0.73 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL3409903 | 0.73 | KMT2A (0.42) | PLAUALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL6518216 | 0.72 | PPID (0.59) | ALDH1A1L3MBTL1MAPK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8053510 | 0.72 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL17505967 | 0.71 | S1PR1 (0.43) | ALDH1A1L3MBTL1MAPK1MEN1KMT2A | |
| SCHEMBL21960006 | 0.71 | LMNA (0.56) | ALDH1A1L3MBTL1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL2135402 | 0.71 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1MAPK1MEN1MAPT | |
| SCHEMBL31174375 | 0.71 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1MAPK1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962834-B2 | Modulators of amyloid beta | HOFFMANN-LA ROCHE INC. (US) | 2015-02-24 | — | — | US | disclosed |
| EP-2257541-B1 | MODULATORS FOR AMYLOID BETA | HOFFMANN LA ROCHE (CH) | 2013-08-14 | — | — | EP | disclosed |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | HOFFMANN-LA ROCHE INC. (US) | 2013-07-25 | — | — | US | disclosed |
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | HOFFMANN-LA ROCHE, INC. | 2009-08-27 | — | — | US | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | APP, PSEN1, APOB | PLAU 1568/4885ALDH1A1 2956/4885L3MBTL1 228/4885 |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | APP, PSEN1, APOB | PLAU 1681/4885ALDH1A1 2860/4885L3MBTL1 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.