Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 14/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409944 | 0.83 | MAPT (0.42) | IMPDH2MAPK8MAPK9 | |
| SCHEMBL4106933 | 0.81 | PSEN1 (0.53) | — | |
| SCHEMBL3406191 | 0.80 | IMPDH2 (0.45) | IMPDH2PLK1 | |
| SCHEMBL3410455 | 0.79 | MEN1 (0.42) | IMPDH2PLK1MAPK8MAPK9 | |
| SCHEMBL3413146 | 0.77 | IMPDH2 (0.40) | IMPDH2PLK1MAPK8MAPK9BRAF | |
| SCHEMBL3408509 | 0.75 | CDK9 (0.40) | SYK | |
| SCHEMBL3410488 | 0.74 | BRD4 (0.40) | IMPDH2PLK1 | |
| SCHEMBL3410539 | 0.74 | MAPT (0.43) | IMPDH2MAPK8MAPK9 | |
| SCHEMBL3409949 | 0.74 | IMPDH2 (0.51) | IMPDH2 | |
| SCHEMBL3412734 | 0.72 | IGF1R (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |