Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411680 | 0.88 | MAPT (0.47) | LMNAALDH1A1KDM4EHTTRAB9A | |
| SCHEMBL3410031 | 0.87 | MAPT (0.52) | LMNAALDH1A1KDM4EHTTRAB9A | |
| SCHEMBL3409992 | 0.81 | POLB (0.50) | LMNAALDH1A1KDM4EHTTRAB9A | |
| SCHEMBL3411549 | 0.81 | NPC1 (0.49) | LMNAALDH1A1KDM4EHTTRAB9A | |
| SCHEMBL3411765 | 0.80 | MAPT (0.43) | LMNAALDH1A1KDM4EHTTTSHR | |
| SCHEMBL3411768 | 0.78 | MAPT (0.46) | LMNAALDH1A1KDM4EHTTTSHR | |
| SCHEMBL3408312 | 0.74 | TDP1 (0.49) | LMNAALDH1A1KDM4EHTTTSHR | |
| SCHEMBL3408224 | 0.73 | MAPT (0.50) | LMNAALDH1A1KDM4EHTTNPSR1 | |
| SCHEMBL3405825 | 0.70 | MAPT (0.55) | LMNAALDH1A1KDM4EHTTTSHR | |
| SCHEMBL2637533 | 0.69 | MAPT (0.50) | LMNATSHRTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | claimed |
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |