Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410031 | 0.89 | MAPT (0.52) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3410083 | 0.81 | LMNA (0.48) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3411680 | 0.81 | MAPT (0.47) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3411765 | 0.79 | MAPT (0.43) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3408224 | 0.77 | MAPT (0.50) | POLBMEN1KMT2AMAPTLMNA | |
| SCHEMBL3411768 | 0.77 | MAPT (0.46) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3411549 | 0.76 | NPC1 (0.49) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3405825 | 0.76 | MAPT (0.55) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3408312 | 0.76 | TDP1 (0.49) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2637592 | 0.75 | MEN1 (0.45) | NPC1RAB9AEGFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | claimed |
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |