Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410031 | 0.84 | MAPT (0.52) | TDP1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3407592 | 0.82 | MAPT (0.50) | TDP1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3408224 | 0.78 | MAPT (0.50) | TDP1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL13597924 | 0.78 | ALDH1A1 (0.71) | TDP1MAPTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL3411768 | 0.76 | MAPT (0.46) | TDP1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3409992 | 0.76 | POLB (0.50) | TDP1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3405825 | 0.75 | MAPT (0.55) | TDP1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3410083 | 0.74 | LMNA (0.48) | TDP1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3411499 | 0.74 | MAPT (0.47) | TDP1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3411765 | 0.74 | MAPT (0.43) | TDP1MAPTL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | claimed |
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |