Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MST1R | Q04912 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2423137 | 0.85 | MET (0.67) | METKDRMST1RAURKBALK | |
| SCHEMBL3410098 | 0.82 | MET (0.64) | METMST1R | |
| SCHEMBL3412907 | 0.79 | MET (0.55) | METKDRMST1RAURKBALK | |
| SCHEMBL15387385 | 0.77 | MET (0.52) | METKDRMST1RAURKBALK | |
| SCHEMBL2422654 | 0.74 | MET (0.73) | METKDRMST1RAURKBALK | |
| SCHEMBL12287485 | 0.71 | MET (0.75) | METKDRMST1RAURKBALK | |
| SCHEMBL1821346 | 0.69 | MAP4K3 (0.61) | METRIPK1KDRMST1RAURKB | |
| SCHEMBL3416381 | 0.69 | MET (0.53) | METKDRMST1RAURKBALK | |
| SCHEMBL2423767 | 0.69 | MET (0.52) | METKDRMST1RAURKBALK | |
| SCHEMBL3408021 | 0.68 | MET (0.46) | METKDRMST1RAURKBALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265616-A1 | FURO-AND THIENO[3,2-C]PYRIDINES | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009100282-A1 | FURO-AND THIENO[3,2-C] PYRIDINES | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |