Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dextrothyroxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 11/20 | 0.76 |
| ▸ | THRA known ✓ | P10827 | 7/20 | 0.76 |
| ▸ | MEN1 | O00255 | 7/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.76 |
| ▸ | LMNA | P02545 | 5/20 | 0.76 |
| ▸ | PPARG | P37231 | 5/20 | 0.76 |
| ▸ | USP2 | O75604 | 4/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.76 |
| ▸ | TTR | P02766 | 2/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | RXRA | P19793 | 2/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextrothyroxine SCHEMBL582058 | 1.00 | THRB (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL5498887 | 1.00 | THRB (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL1995243 | 1.00 | THRB (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL7112166 | 0.99 | USP2 (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL2327406 | 0.99 | USP2 (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL838270 | 0.99 | USP2 (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL1560691 | 0.95 | THRB (0.86) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL4965467 | 0.95 | THRB (0.86) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL15569465 | 0.92 | THRB (0.91) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL4437395 | 0.88 | THRB (0.61) | THRBMEN1KMT2ATHRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8375 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636270-B2 | Levothyroxine liquid formulations | FRESENIUS KABI USA, LLC (US) | 2026-05-26 | — | — | US | claimed |
| US-20260076932-A1 | STABLE LEVOTHYROXINE COMPOSITIONS IN APROTIC POLAR SOLVENTS | XERIS PHARMACEUTICALS, INC. (US) | 2026-03-19 | — | — | US | claimed |
| US-12514837-B2 | Stable levothyroxine compositions in aprotic polar solvents | XERIS PHARMACEUTICALS, INC. (US) | 2026-01-06 | — | — | US | claimed |
| US-20250268830-A1 | SUSTAINED RELEASE INJECTABLE PHARMACEUTICAL FORMULATION OF LEVOTHYROXINE AND PROCESS FOR PREPARATION THEREOF | PHARMATHEN S.A. (GR) | 2025-08-28 | — | — | US | claimed |
| EP-4604922-A1 | STABLE LEVOTHYROXINE COMPOSITIONS IN APROTIC POLAR SOLVENTS | Xeris Pharmaceuticals, Inc. (US) | 2025-08-27 | — | — | EP | claimed |
| EP-4602049-A1 | SOS1 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2025-08-20 | — | — | EP | claimed |
| EP-4587439-A1 | SULFONE-SUBSTITUTED PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | Bayer Aktiengesellschaft (DE) | 2025-07-23 | — | — | EP | claimed |
| US-12364682-B2 | Use of tegaserod in preparation of anti-tumor drug | QINGDAO HAIJI BIOMEDICINE CO., LTD. (CN) | 2025-07-22 | — | — | US | claimed |
| CN-120152698-A | Sustained release injectable formulations using aprotic polar solvents | XERIS药物公司 | 2025-06-13 | — | — | CN | claimed |
| CN-120076788-A | Stable levothyroxine compositions in aprotic polar solvents | XERIS药物公司 | 2025-05-30 | — | — | CN | claimed |
| CN-1156591-A | Oxytocic aid for fishes and hasten parturition method thereof | QIAN JIADA (CN) | 1997-08-13 | — | — | CN | claimed |
| WO-1997019703-A2 | THYROXINE/CYCLODEXTRIN COMPLEXES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | HEXAL AG (DE) | 1997-06-05 | — | — | WO | claimed |
| US-5635209-A | MIXING WITH A POTASSIUM IODIDE STABILIZER, A DISINTEGRANT A LUBRICANT AND A CARRIER; PHOTOSTABILITY; HEAT RESISTANCE; HUMIDITY; SHELF LIFE | VINTAGE PHARMACEUTICALS, INC. (US) | 1997-06-03 | — | — | US | claimed |
| WO-1997017951-A1 | STABILIZED THYROID HORMONE PREPARATIONS AND METHODS OF MAKING SAME | KNOLL PHARMACEUTICAL COMPANY (US) | 1997-05-22 | — | — | WO | claimed |
| EP-0751769-A1 | MEDICAL TREATMENT USING THYROID HORMONES | The Regents of The University of Michigan (US) | 1997-01-08 | — | — | EP | claimed |
| US-5571840-A | ADMINISTERING LEVOTHYROXINE | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-11-05 | — | — | US | claimed |
| WO-1995000135-A1 | MEDICAL TREATMENT USING THYROID HORMONES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1995-01-05 | — | — | WO | claimed |
| US-5225204-A | Stable dosage of levothyroxine sodium and process of production | KNOLL BV (NL) | 1993-07-06 | — | — | US | claimed |
| US-4654331-A | Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group | MERCK & CO., INC. (US) | 1987-03-31 | — | — | US | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |