Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dextrothyroxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 11/20 | 0.76 |
| ▸ | THRA known ✓ | P10827 | 7/20 | 0.76 |
| ▸ | MEN1 | O00255 | 7/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.76 |
| ▸ | LMNA | P02545 | 5/20 | 0.76 |
| ▸ | PPARG | P37231 | 5/20 | 0.76 |
| ▸ | USP2 | O75604 | 4/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.76 |
| ▸ | TTR | P02766 | 2/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | RXRA | P19793 | 2/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextrothyroxine SCHEMBL582058 | 1.00 | THRB (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL5498887 | 1.00 | THRB (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL34102 | 1.00 | THRB (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL7112166 | 0.99 | USP2 (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL2327406 | 0.99 | USP2 (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL838270 | 0.99 | USP2 (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL1560691 | 0.95 | THRB (0.86) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL4965467 | 0.95 | THRB (0.86) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL15569465 | 0.92 | THRB (0.91) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL4437395 | 0.88 | THRB (0.61) | THRBMEN1KMT2ATHRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513044-B1 | PROCESS FOR THE PREPARATION OF THYROID HORMONES AND SALTS THEREOF | BRACCO IMAGING SPA (IT) | 2017-07-12 | — | — | EP | disclosed |
| US-8759572-B2 | Process for the preparation of thyroid hormones and salts thereof | BRACCO IMAGING S.P.A. (IT) | 2014-06-24 | — | — | US | disclosed |
| US-20120296113-A1 | Process For The Preparation Of Thyroid Hormones And Salts Thereof | BRACCO IMAGING S.P.A. (IT) | 2012-11-22 | — | — | US | disclosed |
| EP-2513044-A1 | PROCESS FOR THE PREPARATION OF THYROID HORMONES AND SALTS THEREOF | Bracco Imaging S.p.A (IT) | 2012-10-24 | — | — | EP | disclosed |
| EP-2338875-A1 | Process for the preparation of thyroid hormones and derivatives thereof | Bracco Imaging S.p.A (IT) | 2011-06-29 | — | — | EP | disclosed |
| WO-2011073409-A1 | PROCESS FOR THE PREPARATION OF THYROID HORMONES AND SALTS THEREOF | BRACCO IMAGING SPA (IT) | 2011-06-23 | — | — | WO | disclosed |
| US-7706874-B2 | Stimulating cranial nerve to treat disorders associated with the thyroid gland | CYBERONICS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20070027483-A1 | Stimulating cranial nerve to treat disorders associated with the thyroid gland | CYBERONICS, INC. | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296113-A1 | Process For The Preparation Of Thyroid Hormones And Salts Thereof | TPO, TSHR, THRA | THRB 4/4885THRA 3/4885MEN1 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.