Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dextrothyroxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 11/20 | 0.76 |
| ▸ | THRA known ✓ | P10827 | 7/20 | 0.76 |
| ▸ | MEN1 | O00255 | 7/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.76 |
| ▸ | LMNA | P02545 | 5/20 | 0.76 |
| ▸ | PPARG | P37231 | 5/20 | 0.76 |
| ▸ | USP2 | O75604 | 4/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.76 |
| ▸ | TTR | P02766 | 2/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | RXRA | P19793 | 2/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextrothyroxine SCHEMBL582058 | 1.00 | THRB (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL1995243 | 1.00 | THRB (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL34102 | 1.00 | THRB (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL7112166 | 0.99 | USP2 (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL2327406 | 0.99 | USP2 (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL838270 | 0.99 | USP2 (0.76) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL1560691 | 0.95 | THRB (0.86) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL4965467 | 0.95 | THRB (0.86) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL15569465 | 0.92 | THRB (0.91) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL4437395 | 0.88 | THRB (0.61) | THRBMEN1KMT2ATHRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737539-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | Warner-Lambert Company LLC (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005099823-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | WARNER-LAMBERT COMPANY LLC (US) | 2005-10-27 | — | — | WO | disclosed |