Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2869557 | 0.82 | GFER (0.40) | NPC1RAB9AKDM4ETDP1HKDC1 | |
| SCHEMBL2866012 | 0.80 | PDE10A (0.39) | NPC1RAB9AKDM4ETDP1HKDC1 | |
| SCHEMBL2855234 | 0.79 | MEN1 (0.44) | NPC1RAB9AKDM4EL3MBTL1PDE10A | |
| SCHEMBL2862836 | 0.78 | ALDH1A1 (0.40) | NPC1RAB9APDE10AMEN1KMT2A | |
| SCHEMBL2859516 | 0.78 | PDE10A (0.37) | NPC1RAB9AKDM4ETDP1HKDC1 | |
| SCHEMBL2863729 | 0.76 | NTRK1 (0.38) | NPC1RAB9AKDM4ETDP1HKDC1 | |
| SCHEMBL3433640 | 0.76 | MEN1 (0.37) | NPC1RAB9AKDM4ETDP1HKDC1 | |
| SCHEMBL15286657 | 0.76 | NPC1 (0.55) | NPC1RAB9AKDM4ETDP1HKDC1 | |
| SCHEMBL3407557 | 0.75 | IRAK4 (0.33) | NPC1RAB9AKDM4ETDP1HKDC1 | |
| SCHEMBL2858382 | 0.75 | ALDH1A1 (0.40) | L3MBTL1PDE10ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370260-B1 | AZOLES AS MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2010-11-24 | — | — | EP | claimed |