Doxazosin

Doxazosin

SCHEMBL34111

COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)CC3)nc(N)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1D

The experimentally established mechanism targets of Doxazosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1D known ✓ P25100 1/20 1.00
ADRA1A known ✓ P35348 1/20 1.00
ADRA1B known ✓ P35368 1/20 1.00
KMT2A Q03164 3/20 1.00
MMP1 P03956 1/20 1.00
ADRB2 P07550 1/20 1.00
CHRM2 P08172 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
CHRM1 P11229 1/20 1.00
ADRB3 P13945 1/20 1.00
ADRA2B P18089 1/20 1.00
ADRA2C P18825 1/20 1.00
DRD1 P21728 1/20 1.00
TBXA2R P21731 1/20 1.00
SLC6A2 P23975 1/20 1.00
HRH2 P25021 1/20 1.00
TACR1 P25103 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Doxazosin SCHEMBL30772126 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL1648487 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL97513 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL29711371 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL29688095 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL29641831 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL8523145 0.99 KMT2A (0.98) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL6479014 0.99 KMT2A (0.98) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL612310 0.99 KMT2A (0.98) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL5201447 0.97 KMT2A (0.95) KMT2AMMP1ADRB2CHRM2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 26599 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
EP-3426310-B1 PROSTATIC LIQUID BIOPSY FOR THE DETECTION OF PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA WAVESENSE INC (US) 2026-05-06 EP claimed
WO-2026090251-A1 METHODS FOR IMPROVING TREATMENT OUTCOMES IN PATIENTS UNDERGOING ULTRAFILTRATION PROLETARIAT THERAPEUTICS, INC. (US) 2026-04-30 WO claimed
EP-4727545-A2 COMBINATION TREATMENTS FOR DEPRESSION AND OTHER DISORDERS Neurawell Therapeutics (US) 2026-04-22 EP claimed
US-12590181-B2 Hydrophobically-modified associative thickener polymers process for the preparation and uses thereof HERCULES LLC (US) 2026-03-31 US claimed
WO-2026042047-A1 COMPOSITIONS AND ARTICLES COMPRISING REVERSIBLE COMPLEXES OF CROSSLINKED CARRAGEENAN JOHNSON & JOHNSON VISION CARE, INC. (US) 2026-02-26 WO claimed
EP-3930839-B1 ONVANSERTIB FOR INHIBITING NON-ADRENERGIC CONTRACTION OF SMOOTH MUSCLE AND PROSTATE CELL PROLIFERATION CARDIFF ONCOLOGY INC (US) 2026-01-28 EP claimed
EP-4656194-A1 COMPOSITION FOR PREVENTING OR TREATING POST-TRAUMATIC STRESS DISORDER, COMPRISING PHOSPHODIESTERASE TYPE 5 INHIBITOR AS ACTIVE INGREDIENT Aribio Co., Ltd (KR) 2025-12-03 EP claimed
EP-4192923-B1 HYDROPHOBICALLY-MODIFIED ASSOCIATIVE THICKENER POLYMERS PROCESS FOR THE PREPARATION AND USES THEREOF HERCULES LLC (US) 2025-10-29 EP claimed
US-20250302887-A1 AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE AOBIOME LLC (US) 2025-10-02 US claimed
EP-0294993-A1 A generic zero order controlled drug delivery system PFIZER INC. (US) 1988-12-14 EP claimed
US-4765989-A SEMIPERMEABLE MATERIAL SURROUNDS COMPARTMENT ALZA CORPORATION (US) 1988-08-23 US claimed
US-4758569-A Doxazosin as an anti-atherosclerosis agent PFIZER INC. (US) 1988-07-19 US claimed
EP-0271983-A1 Transdermal flux enhancing compositions PFIZER INC. (US) 1988-06-22 EP claimed
EP-0259113-A2 Controlled release device for an active substance PFIZER INC. (US) 1988-03-09 EP claimed
US-4659714-A PROLONGATION WITH VASOCONSTRICTORS; REVERSAL WITH ADRENERGIC BLOCKING AGENTS DENTSPLY, LTD. (GB) 1987-04-21 US claimed
EP-0189336-A1 Pharmaceutical compositions containing an alpha-blocker and a calcium antagonist SYNTHELABO (FR) 1986-07-30 EP claimed
EP-0160191-A1 Kit for treating mammals Dentsply Limited (GB) 1985-11-06 EP claimed
US-4532135-A Treating renal damage by administering vasodilator having postsynaptic alpha-adrenoceptor blocking activity and antihyperlipidemic characteristics EDWARDS K DAVID G 1985-07-30 US claimed
US-4188390-A Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines PFIZER INC. (US) 1980-02-12 US claimed