Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxazosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.98 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.98 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.98 |
| ▸ | MMP1 | P03956 | 1/20 | 0.98 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | DRD1 | P21728 | 1/20 | 0.98 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.98 |
| ▸ | HRH2 | P25021 | 1/20 | 0.98 |
| ▸ | TACR1 | P25103 | 1/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | HTR2C | P28335 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxazosin SCHEMBL34111 | 0.99 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL30772126 | 0.99 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL29688095 | 0.99 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL1648487 | 0.99 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL29641831 | 0.99 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL97513 | 0.99 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL29711371 | 0.99 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL612310 | 0.98 | KMT2A (0.98) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL8523145 | 0.98 | KMT2A (0.98) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL5201447 | 0.97 | KMT2A (0.95) | KMT2AMMP1ADRB2CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511484-A1 | COMBINATION OF A DPP IV INHIBITOR AND A CARDIOVASCULAR COMPOUND | Novartis AG (CH) | 2005-03-09 | — | — | EP | claimed |
| WO-2003099279-A1 | COMBINATION OF A DPP IV INHIBITOR AND A CARDIOVASCULAR COMPOUND | NOVARTIS AG (CH) | 2003-12-04 | — | — | WO | claimed |