Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxazosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.95 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.95 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.95 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.95 |
| ▸ | MMP1 | P03956 | 1/20 | 0.95 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.95 |
| ▸ | HTR1A | P08908 | 1/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.95 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.95 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.95 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.95 |
| ▸ | DRD1 | P21728 | 1/20 | 0.95 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.95 |
| ▸ | HRH2 | P25021 | 1/20 | 0.95 |
| ▸ | TACR1 | P25103 | 1/20 | 0.95 |
| ▸ | HTR2A | P28223 | 1/20 | 0.95 |
| ▸ | HTR2C | P28335 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxazosin SCHEMBL1648487 | 0.97 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL97513 | 0.97 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL29641831 | 0.97 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL29711371 | 0.97 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL29688095 | 0.97 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL30772126 | 0.97 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL34111 | 0.97 | KMT2A (1.00) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL6479014 | 0.97 | KMT2A (0.98) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL8523145 | 0.97 | KMT2A (0.98) | KMT2AMMP1ADRB2CHRM2HTR1A | |
| Doxazosin SCHEMBL612310 | 0.97 | KMT2A (0.98) | KMT2AMMP1ADRB2CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0849266-B1 | Novel polymorphic form of doxazosin mesylate (form III) | HEUMANN PHARMA GMBH & CO (DE) | 2007-02-14 | — | — | EP | claimed |
| US-6140334-A | Polymorphic form of doxazosin mesylate (form III) | HEUMANN PHARMA GMBH (DE) | 2000-10-31 | — | — | US | claimed |
| JP-10182641-A | — | — | None | — | — | JP | disclosed |
| US-6140334-A | Polymorphic form of doxazosin mesylate (form III) | HEUMANN PHARMA GMBH (DE) | 2000-10-31 | — | — | US | disclosed |
| JP-H10182641-A | NEW FORM III OF DOXAZOSIN MESYLATE | HEUMANN PHARMA GMBH | 1998-07-07 | — | — | JP | disclosed |