Doxazosin

Doxazosin

SCHEMBL97513

COc1cc2nc(N3CCN(C(=O)[C@H]4COc5ccccc5O4)CC3)nc(N)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1D

The experimentally established mechanism targets of Doxazosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1D known ✓ P25100 1/20 1.00
ADRA1A known ✓ P35348 1/20 1.00
ADRA1B known ✓ P35368 1/20 1.00
KMT2A Q03164 3/20 1.00
MMP1 P03956 1/20 1.00
ADRB2 P07550 1/20 1.00
CHRM2 P08172 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
CHRM1 P11229 1/20 1.00
ADRB3 P13945 1/20 1.00
ADRA2B P18089 1/20 1.00
ADRA2C P18825 1/20 1.00
DRD1 P21728 1/20 1.00
TBXA2R P21731 1/20 1.00
SLC6A2 P23975 1/20 1.00
HRH2 P25021 1/20 1.00
TACR1 P25103 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Doxazosin SCHEMBL30772126 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL1648487 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL34111 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL29711371 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL29688095 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL29641831 1.00 KMT2A (1.00) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL8523145 0.99 KMT2A (0.98) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL6479014 0.99 KMT2A (0.98) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL612310 0.99 KMT2A (0.98) KMT2AMMP1ADRB2CHRM2HTR1A
Doxazosin SCHEMBL5201447 0.97 KMT2A (0.95) KMT2AMMP1ADRB2CHRM2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7150 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590181-B2 Hydrophobically-modified associative thickener polymers process for the preparation and uses thereof HERCULES LLC (US) 2026-03-31 US claimed
EP-4192923-B1 HYDROPHOBICALLY-MODIFIED ASSOCIATIVE THICKENER POLYMERS PROCESS FOR THE PREPARATION AND USES THEREOF HERCULES LLC (US) 2025-10-29 EP claimed
US-20250302887-A1 AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE AOBIOME LLC (US) 2025-10-02 US claimed
CN-119955108-A Nonionic aqueous hydroxyl-containing polyacrylate secondary dispersion, and preparation method and application thereof 上海华谊涂料有限公司 2025-05-09 CN claimed
CN-119875714-A Synthetic ester refrigeration equipment lubricant 刚和石油(营口)有限公司 2025-04-25 CN claimed
US-20250090602-A1 AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE AOBIOME LLC (US) 2025-03-20 US claimed
CN-116324124-B Hydrophobically modified associative thickener polymer and preparation method and application thereof 赫尔克里士有限公司 2025-03-18 CN claimed
CN-116324123-B Hydrophobically modified associative thickener polymer and preparation method and application thereof 赫尔克里士有限公司 2025-03-18 CN claimed
US-12098237-B2 Curable resin composition ALLNEX BELGIUM S.A. (BE) 2024-09-24 US claimed
US-20240299465-A1 AMMONIA OXIDIZING MICROORGANISMS FOR THE REGULATION OF BLOOD PRESSURE AOBIOME LLC (US) 2024-09-12 US claimed
EP-1407785-A1 MEDICINAL COMPOSITIONS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2004-04-14 EP claimed
JP-2002541273-A 2002-12-03 JP claimed
US-20020049155-A1 Cobalamin compounds useful as cardiovascular agents and as imaging agents HOGENKAMP HENRICUS P C (US) 2002-04-25 US claimed
EP-1171475-A1 THERMOSETTING RESIN COMPOSITIONS COMPRISING CROSS-LINKED REACTIVE MICROPARTICLES WITH IMPROVED MECHANICAL STRENGTH CRAY VALLEY SA (FR) 2002-01-16 EP claimed
EP-1169354-A1 CROSS-LINKED MICROPARTICLES, METHOD FOR THE PRODUCTION AND USE THEREOF CRAY VALLEY SA (FR) 2002-01-09 EP claimed
WO-2001092283-A2 COBALAMIN COMPOUNDS USEFUL AS CARDIOVASCULAR AGENTS AND AS IMAGING AGENTS MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2001-12-06 WO claimed
US-20010028897-A1 Compositions and treatment methods for benign prostatic hypertrophy HAMMERLY MILTON (US) 2001-10-11 US claimed
WO-2000059953-A9 THERMOSETTING RESIN COMPOSITIONS COMPRISING CROSS-LINKED REACTIVE MICROPARTICLES WITH IMPROVED MECHANICAL STRENGTH CRAY VALLEY SA (FR) 2001-03-15 WO claimed
WO-2000059951-A1 CROSS-LINKED MICROPARTICLES, METHOD FOR THE PRODUCTION AND USE THEREOF CRAY VALLEY S.A. (FR) 2000-10-12 WO claimed
WO-2000059953-A1 THERMOSETTING RESIN COMPOSITIONS COMPRISING CROSS-LINKED REACTIVE MICROPARTICLES WITH IMPROVED MECHANICAL STRENGTH CRAY VALLEY SA (FR) 2000-10-12 WO claimed