Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 8/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | FSHR | P23945 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410981 | 0.87 | LIMK1 (0.42) | LIMK1MAPTALDH1A1MEN1GAA | |
| SCHEMBL3406840 | 0.84 | LIMK1 (0.42) | LIMK1MAPTALDH1A1MEN1GAA | |
| SCHEMBL1176165 | 0.84 | LIMK1 (0.56) | LHCGRLIMK1MAPTALDH1A1MEN1 | |
| SCHEMBL3414147 | 0.83 | LIMK1 (0.42) | LIMK1MAPTALDH1A1MEN1GAA | |
| SCHEMBL3406906 | 0.83 | MAPT (0.45) | LHCGRLIMK1MAPTALDH1A1MEN1 | |
| SCHEMBL3413287 | 0.82 | LIMK1 (0.39) | LIMK1MAPTALDH1A1MEN1GAA | |
| SCHEMBL2131565 | 0.82 | LHCGR (0.46) | LHCGRLIMK1MAPTALDH1A1MEN1 | |
| SCHEMBL3407986 | 0.82 | ALDH1A1 (0.40) | LIMK1MAPTALDH1A1MEN1GAA | |
| SCHEMBL3409496 | 0.80 | BRAF (0.40) | LIMK1MAPTALDH1A1MEN1GAA | |
| SCHEMBL2132406 | 0.80 | KDM4E (0.50) | LHCGRLIMK1MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260044-A2 | THIENOPYRIMIDINES | Merck Patent GmbH (DE) | 2010-12-15 | — | — | EP | claimed |
| WO-2009124653-A2 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2009-10-15 | — | — | WO | claimed |