Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12459121 | 0.85 | NOTUM (0.40) | ADORA2AADORA2BNOTUMGPR119MTOR | |
| SCHEMBL29852305 | 0.81 | KMT2A (0.42) | NOTUMGPR119KMT2A | |
| SCHEMBL16452781 | 0.81 | KMT2A (0.42) | NOTUMGPR119KMT2A | |
| SCHEMBL13141206 | 0.79 | NOTUM (0.36) | ADORA2AADORA2BNOTUMGPR119HSD11B1 | |
| SCHEMBL27064600 | 0.79 | CNR2 (0.41) | NOTUMGPR119MTOR | |
| SCHEMBL23054209 | 0.77 | NOTUM (0.36) | ADORA2AADORA2BNOTUMGPR119MTOR | |
| SCHEMBL13179082 | 0.77 | TRPV3 (0.36) | ADORA2AADORA2BNOTUMGPR119HSD11B1 | |
| SCHEMBL13197446 | 0.77 | LIPE (0.41) | NOTUMGPR119HSD11B1PDK1PDK2 | |
| SCHEMBL21981194 | 0.77 | TRPV3 (0.36) | ADORA2AADORA2BNOTUMGPR119HSD11B1 | |
| SCHEMBL13197445 | 0.77 | LIPE (0.41) | NOTUMGPR119HSD11B1PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168659-B2 | 1, 5-diphenyl-3-benzylamino-1, 5-dihydropyrrolidin-2-one as CB1 receptor modulators | ELI LILLY AND COMPANY (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168659-B2 | 1, 5-diphenyl-3-benzylamino-1, 5-dihydropyrrolidin-2-one as CB1 receptor modulators | ELI LILLY AND COMPANY (US) | 2012-05-01 | — | — | US | disclosed |
| EP-2094684-B1 | 1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN 2-ONES AS CB1 RECEPTOR MODULATORS | LILLY CO ELI (US) | 2010-12-22 | — | — | EP | disclosed |
| EP-2094684-B1 | 1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN 2-ONES AS CB1 RECEPTOR MODULATORS | LILLY CO ELI (US) | 2010-12-22 | — | — | EP | disclosed |
| US-20090275618-A1 | 1, 5-DIPHENYL-3-BENZYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS | ELI LILLY AND COMPANY | 2009-11-05 | — | — | US | disclosed |
| US-20090275618-A1 | 1, 5-DIPHENYL-3-BENZYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS | ELI LILLY AND COMPANY | 2009-11-05 | — | — | US | disclosed |
| WO-2008070306-A2 | 1,5-DIPHENYL-3-BENZYLAMIN0-1,5-DIHYDR0PYRR0LIDIN-2-0NE AS CB1 RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275618-A1 | 1, 5-DIPHENYL-3-BENZYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS | CNR1, CNR2, GPR55 | ADORA2A 316/4885ADORA2B 947/4885NOTUM 2442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.