Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 6/20 | 1.00 |
| ▸ | PYGM | P11217 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | TK2 | O00142 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659809 | 1.00 | TK1 (1.00) | TK1PYGMLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL3411578 | 1.00 | TK1 (1.00) | TK1PYGMLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL13314168 | 1.00 | TK1 (1.00) | TK1PYGMLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL9310751 | 0.93 | TK1 (0.86) | TK1PYGMLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL9308657 | 0.85 | TK1 (0.74) | TK1PYGMLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL9309443 | 0.85 | TK1 (0.73) | TK1PYGMLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL13102976 | 0.84 | TK1 (0.72) | TK1LMNABLMADRA1A | |
| SCHEMBL22382008 | 0.84 | TK1 (0.72) | TK1LMNABLMADRA1A | |
| SCHEMBL11187848 | 0.84 | TK1 (0.72) | TK1PYGMLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL11187839 | 0.84 | TK1 (0.72) | TK1PYGMLMNASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4396623-A | Carbocyclic analogs of uracil nucleosides as antiviral agents | SOUTHERN RESEARCH INSTITUTE (US) | 1983-08-02 | — | — | US | claimed |
| US-9382286-B2 | Treatment of EBV and KHSV infection and associated abnormal cellular proliferation | EMORY UNIVERSITY (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382286-B2 | Treatment of EBV and KHSV infection and associated abnormal cellular proliferation | EMORY UNIVERSITY (US) | 2016-07-05 | — | — | US | disclosed |
| US-20140336143-A1 | TREATMENT OF EBV AND KHSV INFECTION AND ASSOCIATED ABNORMAL CELLULAR PROLIFERATION | GILEAD PHARMASSET LLC (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336143-A1 | TREATMENT OF EBV AND KHSV INFECTION AND ASSOCIATED ABNORMAL CELLULAR PROLIFERATION | GILEAD PHARMASSET LLC (US) | 2014-11-13 | — | — | US | disclosed |
| US-20100168052-A1 | Treatment of EBV and KHSV Infection and Associated Abnormal Cellular Proliferation | PHARMASSET, INC. (US) | 2010-07-01 | — | — | US | disclosed |
| US-20100168052-A1 | Treatment of EBV and KHSV Infection and Associated Abnormal Cellular Proliferation | PHARMASSET, INC. (US) | 2010-07-01 | — | — | US | disclosed |
| US-7638502-B2 | Treatment of EBV and KHSV infection and associated abnormal cellular proliferation | PHARMASSET, INC. (US) | 2009-12-29 | — | — | US | disclosed |
| US-20070197462-A1 | Treatment of EBV and KHSV infection and associated abnormal cellular proliferation | PHARMASSET, INC. (US) | 2007-08-23 | — | — | US | disclosed |
| US-7211570-B2 | Administering 5-substituted uracil-nucleosides or its pharmaceutically acceptable salt or prodrug for therapy of infected with Epstein-Barr virus or Kaposi's sarcoma-associated herpes (\"KHSV\") | PHARMASSET, INC. (US) | 2007-05-01 | — | — | US | disclosed |
| US-20030176392-A1 | Administering 5-substituted uracil-nucleosides or its pharmaceutically acceptable salt or prodrug for therapy of infected with Epstein-Barr virus or Kaposi's sarcoma-associated herpes (\"KHSV\") | EMORY UNIVERSITY | 2003-09-18 | — | — | US | disclosed |
| EP-0418007-A2 | Cyclopentane derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-20 | — | — | EP | disclosed |
| US-4719214-A | HERPES VIRUS | SOUTHERN RESEARCH INSTITUTE (US) | 1988-01-12 | — | — | US | disclosed |
| US-4396623-A | Carbocyclic analogs of uracil nucleosides as antiviral agents | SOUTHERN RESEARCH INSTITUTE (US) | 1983-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176392-A1 | Administering 5-substituted uracil-nucleosides or its pharmaceutically acceptable salt or prodrug for therapy of infected with Epstein-Barr virus or Kaposi's sarcoma-associated herpes (\"KHSV\") | UMPS, UNG, TYMP | TK1 5/4885PYGM 1497/4885LMNA 2329/4885 |
| US-20070197462-A1 | Treatment of EBV and KHSV infection and associated abnormal cellular proliferation | UMPS, ENTPD5, TK1 | TK1 3/4885PYGM 2479/4885LMNA 1844/4885 |
| US-20140336143-A1 | TREATMENT OF EBV AND KHSV INFECTION AND ASSOCIATED ABNORMAL CELLULAR PROLIFERATION | UMPS, ENTPD5, TK1 | TK1 3/4885PYGM 2479/4885LMNA 1844/4885 |
| US-20100168052-A1 | Treatment of EBV and KHSV Infection and Associated Abnormal Cellular Proliferation | UMPS, ENTPD5, TK1 | TK1 3/4885PYGM 2479/4885LMNA 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.