Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | PTGIR | P43119 | 2/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12893455 | 0.82 | PTGDR2 (0.49) | PTGDR2CYP3A4CYP2C9TBXA2RPTGIR | |
| SCHEMBL3395957 | 0.82 | PTGDR2 (0.48) | PTGDR2CYP3A4CYP2C9TBXA2RPTGIR | |
| SCHEMBL136241 | 0.81 | PTGDR2 (0.63) | PTGDR2CYP3A4CYP2C9TBXA2RPTGIR | |
| SCHEMBL1922353 | 0.80 | PTGDR2 (0.54) | PTGDR2CYP3A4CYP2C9TBXA2RPTGIR | |
| SCHEMBL137339 | 0.79 | PTGDR2 (0.66) | PTGDR2CYP3A4CYP2C9TBXA2RPTGIR | |
| SCHEMBL139249 | 0.78 | PTGDR2 (0.65) | PTGDR2CYP3A4CYP2C9TBXA2RPTGIR | |
| SCHEMBL137208 | 0.78 | PTGDR2 (0.52) | PTGDR2CYP3A4CYP2C9TBXA2RPTGIR | |
| SCHEMBL13687190 | 0.75 | LMNA (0.62) | PTGDR2ALDH1A1LMNACCR6PAX8 | |
| SCHEMBL12197430 | 0.74 | TRPM8 (0.47) | PTGDR2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL16665613 | 0.73 | ALDH1A1 (0.58) | PTGDR2CYP3A4ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257524-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009099902-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |