Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.48 |
| ▸ | CDK1 | P06493 | 10/20 | 0.48 |
| ▸ | PLK1 | P53350 | 2/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410224 | 0.84 | TP53 (0.43) | KDRPLK1TP53GAAMAPT | |
| SCHEMBL3406186 | 0.84 | KDR (0.42) | KDRPLK1PAK1TP53GAA | |
| SCHEMBL3411191 | 0.81 | BRD4 (0.45) | KDRPLK1SRCPAK1MAPT | |
| SCHEMBL3407305 | 0.80 | PIK3CA (0.61) | PLK1CDK2CDK9 | |
| SCHEMBL3406191 | 0.80 | IMPDH2 (0.45) | KDRCDK1PLK1MAPT | |
| SCHEMBL4091884 | 0.79 | PSEN1 (0.52) | KDRCDK1PAK1 | |
| SCHEMBL3410226 | 0.77 | PLK1 (0.47) | KDRCDK1PLK1CDK2CDK9 | |
| SCHEMBL3406073 | 0.77 | PIK3CA (0.41) | KDRPLK1PRKCQ | |
| SCHEMBL3410488 | 0.76 | BRD4 (0.40) | KDRPLK1 | |
| SCHEMBL3408631 | 0.76 | PIK3CG (0.47) | PLK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |