Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408737 | 0.96 | RET (0.41) | CDK1AURKAAURKBKDRIGF1R | |
| SCHEMBL3410131 | 0.85 | CCNA2 (0.37) | CDK1AURKAAURKBKDRIGF1R | |
| SCHEMBL3408826 | 0.83 | CYP17A1 (0.42) | CDK1AURKAAURKBKDRIGF1R | |
| SCHEMBL3412887 | 0.81 | IGF1R (0.38) | CDK1AURKAAURKBKDRIGF1R | |
| SCHEMBL3412646 | 0.81 | SYK (0.46) | CDK1AURKAAURKBKDRIGF1R | |
| SCHEMBL3406878 | 0.80 | SYK (0.50) | SYK | |
| SCHEMBL3406106 | 0.80 | IGF1R (0.41) | CDK1AURKAAURKBKDRIGF1R | |
| SCHEMBL3409536 | 0.80 | RET (0.40) | CDK1AURKAAURKBKDRIGF1R | |
| SCHEMBL3410060 | 0.80 | ALK (0.46) | IGF1REGFRLCKZAP70SYK | |
| SCHEMBL3409713 | 0.79 | TGFBR1 (0.36) | EHMT2EHMT1PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |