Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409736 | 0.96 | HCRTR1 (0.36) | HCRTR1HCRTR2ACLYOPRM1OPRK1 | |
| SCHEMBL3405479 | 0.92 | HCRTR1 (0.37) | HCRTR1HCRTR2NPC1FKBP1AACLY | |
| SCHEMBL3410497 | 0.89 | HCRTR1 (0.36) | HCRTR1HCRTR2MEN1KMT2AFKBP1A | |
| SCHEMBL3406135 | 0.89 | HCRTR1 (0.36) | HCRTR1HCRTR2NPC1RAB9AMEN1 | |
| SCHEMBL3407386 | 0.85 | HCRTR1 (0.36) | HCRTR1HCRTR2RAB9AFKBP1AACLY | |
| SCHEMBL3410534 | 0.84 | HCRTR1 (0.37) | HCRTR1HCRTR2ACLYOPRM1OPRK1 | |
| SCHEMBL3408516 | 0.83 | HCRTR1 (0.36) | HCRTR1HCRTR2MEN1KMT2AFKBP1A | |
| SCHEMBL3406849 | 0.83 | OPRM1 (0.39) | HCRTR1HCRTR2ACLYOPRM1OPRK1 | |
| SCHEMBL3408874 | 0.81 | HCRTR1 (0.38) | HCRTR1HCRTR2SMN1; SMN2FKBP1AACLY | |
| SCHEMBL3409667 | 0.81 | HCRTR1 (0.38) | HCRTR1HCRTR2ACLYOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257527-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-08 | — | — | EP | claimed |
| US-20090253669-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-08 | — | — | US | claimed |
| WO-2009115257-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-09-24 | — | — | WO | claimed |
| EP-2257527-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-08 | — | — | EP | disclosed |
| US-20090253669-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| WO-2009115257-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253669-A1 | Substituted Sulfonamide Compounds | SULT2A1, STS, SULT1A1 | HCRTR1 4142/4885HCRTR2 3980/4885NPC1 2399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.