SCHEMBL3413433

SCHEMBL3413433

Cc1ccc(C(Br)C=O)c(C)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.35
TP53 P04637 1/20 0.35
TRPA1 O75762 1/20 0.35
LMNA P02545 1/20 0.35
CHRM1 P11229 1/20 0.35
SLC6A2 P23975 1/20 0.35
ADRA1A P35348 1/20 0.35
HTR2B P41595 1/20 0.35
SRC P12931 1/20 0.34
CASR P41180 1/20 0.33
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
CYP2A6 P11509 3/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
CYP3A4 P08684 1/20 0.32
ADRA2A P08913 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
ELANE P08246 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL929896 0.84 LMNA (0.38) TDP1TP53TRPA1LMNACHRM1
SCHEMBL15111101 0.82 CA1 (0.33) LMNACYP2A6MEN1KMT2AALDH1A1
SCHEMBL2489407 0.81 HDAC4 (0.33) ALDH1A1MAPT
SCHEMBL846656 0.81 GABRA1 (0.33) TP53TRPA1LMNACHRM1SLC6A2
SCHEMBL6443568 0.81 ESR1 (0.41) CHRM1ADRA1AHTR2BMAOAMAOB
SCHEMBL27766137 0.78 TRPA1 (0.41) TDP1TP53TRPA1LMNACHRM1
SCHEMBL9751714 0.77 TRPA1 (0.43) TDP1TP53TRPA1LMNACHRM1
SCHEMBL9901514 0.77 ALKBH3 (0.35) LMNAMAOAMAOBCYP2A6MEN1
SCHEMBL22346875 0.77 CYP3A4 (0.33) CYP3A4
SCHEMBL21091489 0.76 TDP1 (0.42) TDP1TP53TRPA1LMNACHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3344997-A1 OPIOID RECEPTOR MODULATORS AND USE THEREOF Regents of the University of Minnesota (US) 2018-07-11 EP disclosed
EP-3215505-A1 PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE Bayer Pharma Aktiengesellschaft (DE) 2017-09-13 EP disclosed
WO-2017039778-A1 OPIOID RECEPTOR MODULATORS AND USE THEREOF REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2017-03-09 WO disclosed
WO-2016071216-A1 PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-05-12 WO disclosed
EP-2970193-A1 PYRROLE AMIDE INHIBITORS AbbVie Inc. (US) 2016-01-20 EP disclosed
WO-2014165127-A1 PYRROLE AMIDE INHIBITORS ABBVIE INC. (US) 2014-10-09 WO disclosed
EP-2758380-A1 BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2014-07-30 EP disclosed
WO-2013041468-A1 BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-28 WO disclosed
EP-2265606-A1 HEPATITIS C VIRUS INHIBITORS Bristol-Myers Squibb Company (US) 2010-12-29 EP disclosed
EP-2125736-A1 SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS Leo Pharma A/S (DK) 2009-12-02 EP disclosed
WO-2009129109-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-10-22 WO disclosed
WO-2008077404-A1 SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS LEO PHARMA A/S (DK) 2008-07-03 WO disclosed
WO-2006057503-A1 NOVEL COMPOUNDS AS AGONIST FOR PPARϜ AND PPARα, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES, LTD. (KR) 2006-06-01 WO disclosed