Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | RORC | P51449 | 5/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PIEZO1 | Q92508 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629490 | 0.86 | TAAR1 (0.41) | TRPV1TAAR1GAAL3MBTL1SMN1; SMN2 | |
| SCHEMBL12812210 | 0.85 | TAAR1 (0.41) | TAAR1RORCPTGS2AKR1B1TYK2 | |
| SCHEMBL16941916 | 0.81 | HSD11B1 (0.41) | TAAR1RORCPIEZO1SMN1; SMN2 | |
| SCHEMBL27955417 | 0.81 | TAAR1 (0.39) | TAAR1RORCPTGS2AKR1B1TYK2 | |
| SCHEMBL28177743 | 0.81 | AKR1B1 (0.42) | TRPV1RORCPTGS2AKR1B1TYK2 | |
| SCHEMBL908383 | 0.80 | TAAR1 (0.58) | TAAR1AKR1B1GAASMN1; SMN2 | |
| SCHEMBL10701891 | 0.78 | TAAR1 (0.36) | TRPV1TAAR1L3MBTL1SMN1; SMN2 | |
| SCHEMBL3012144 | 0.77 | MEN1 (0.39) | TAAR1RORCPTGS2GAAPIEZO1 | |
| SCHEMBL28177744 | 0.77 | RORC (0.36) | TAAR1RORCPTGS2AKR1B1TYK2 | |
| SCHEMBL29393476 | 0.77 | P2RX7 (0.41) | TAAR1RORCPTGS2AKR1B1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2884977-A2 | N-ALKYLATED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | Merck Sharp & Dohme Corp. (US) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014028591-A2 | N-ALKYLATED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2014-02-20 | — | — | WO | disclosed |
| WO-2014026329-A1 | N-ALKYLATED INDOLE AND INDAZOLE COMPOUNDS AS RORGAMMAT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2014-02-20 | — | — | WO | disclosed |
| EP-2265616-A1 | FURO-AND THIENO[3,2-C]PYRIDINES | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009100282-A1 | FURO-AND THIENO[3,2-C] PYRIDINES | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |