Brucine

Brucine

SCHEMBL341490

COc1cc2c(cc1OC)[C@@]13CCN4CC5=CCO[C@H]6CC(=O)N2[C@H]1[C@H]6[C@H]5C[C@H]43.Nc1ccc(S(=O)(=O)O)cc1

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TAS2R10 Q9NYW0 2/20 0.82
CHRM1 P11229 1/20 0.82
SMN1; SMN2 Q16637 1/20 0.82
GLRA1 P23415 14/20 0.69
GLRB P48167 12/20 0.69
CYP3A4 P08684 2/20 0.61
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
SCN1A P35498 1/20 0.61
TAS2R46 P59540 1/20 0.61
SCN2A Q99250 1/20 0.61
SCN3A Q9NY46 1/20 0.61
CYP1A2 P05177 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Brucine SCHEMBL30616038 0.93 TAS2R10 (0.92) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB
Brucine SCHEMBL29686201 0.92 TAS2R10 (0.91) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB
Brucine SCHEMBL14029321 0.90 TAS2R10 (1.00) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB
Brucine SCHEMBL12293782 0.90 TAS2R10 (1.00) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB
Brucine SCHEMBL29391712 0.90 TAS2R10 (1.00) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB
Brucine SCHEMBL23468158 0.90 TAS2R10 (1.00) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB
Brucine SCHEMBL19476145 0.90 TAS2R10 (1.00) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB
Brucine SCHEMBL10307298 0.90 TAS2R10 (1.00) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB
Brucine SCHEMBL1648976 0.90 TAS2R10 (1.00) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB
Brucine SCHEMBL6265047 0.90 TAS2R10 (0.84) TAS2R10CHRM1SMN1; SMN2GLRA1GLRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021215439-A1 MICROALGAE GROWTH PROMOTER AND METHOD FOR PRODUCING MICROALGAE GROWTH PROMOTER 環境大善株式会社 (JP) 2021-10-28 WO disclosed
WO-2017211934-A1 BIOCONTROLLED FERTILISER NUBIOTRIENT IVS (DK) 2017-12-14 WO disclosed
US-8962336-B2 Soil diagnosis and improvement method THE RITSUMEIKAN TRUST (JP) 2015-02-24 US disclosed
US-20140374344-A1 METHOD FOR TREATING WASTEWATER CONTAINING AMMONIA NITROGEN SUMITOMO HEAVY INDUSTRIES (JP) 2014-12-25 US disclosed
EP-2447221-A1 METHOD FOR TREATING WASTEWATER CONTAINING AMMONIA NITROGEN Sumitomo Heavy Industries, LTD. (JP) 2012-05-02 EP disclosed
US-20120097606-A1 METHOD FOR TREATING WASTEWATER CONTAINING AMMONIA NITROGEN SUMITOMO HEAVY INDUSTRIES, LTD. (JP) 2012-04-26 US disclosed
US-20120014748-A1 NOVEL SOIL DIAGNOSIS METHOD THE RITSUMEIKAN TRUST (JP) 2012-01-19 US disclosed