Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 1/20 | 0.65 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | CCR5 | P51681 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680227 | 0.87 | USP28 (0.68) | USP28USP25HTTCCR5ALDH1A1 | |
| SCHEMBL23275535 | 0.83 | LRRK2 (0.54) | USP28USP25HTTCCR5ALDH1A1 | |
| SCHEMBL3416114 | 0.83 | USP28 (0.61) | USP28USP25HTTCCR5ALDH1A1 | |
| SCHEMBL23275276 | 0.82 | MEN1 (0.56) | USP28USP25HTTCCR5ALDH1A1 | |
| SCHEMBL23275101 | 0.81 | LRRK2 (0.51) | USP28USP25HTTCCR5ALDH1A1 | |
| SCHEMBL22786944 | 0.80 | USP28 (0.58) | USP28USP25HTTCCR5ALDH1A1 | |
| SCHEMBL3418906 | 0.80 | CCR5 (0.64) | USP28USP25HTTCCR5ALDH1A1 | |
| SCHEMBL8807552 | 0.80 | CCR5 (0.65) | USP28USP25HTTCCR5ALDH1A1 | |
| SCHEMBL23275493 | 0.80 | CCR5 (0.63) | USP28USP25HTTCCR5ALDH1A1 | |
| SCHEMBL5305401 | 0.79 | LMNA (0.60) | ALDH1A1LMNARAB9APTGER1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| EP-1394147-A1 | CARBOXYLIC ACID DERIVATIVE AND MEDICINE COMPRISING SALT OR ESTER OF THE SAME | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |