SCHEMBL3416144

SCHEMBL3416144

FC=CCn1cnc2c(Cl)nc(Cl)nc21

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 2/20 0.46
HDAC3 O15379 3/20 0.38
HDAC4 P56524 3/20 0.38
HDAC1 Q13547 3/20 0.38
HDAC7 Q8WUI4 3/20 0.38
HDAC2 Q92769 3/20 0.38
HDAC10 Q969S8 3/20 0.38
HDAC11 Q96DB2 3/20 0.38
HDAC8 Q9BY41 3/20 0.38
HDAC6 Q9UBN7 3/20 0.38
HDAC9 Q9UKV0 3/20 0.38
HDAC5 Q9UQL6 3/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
AHCY P23526 2/20 0.38
YTHDC1 Q96MU7 6/20 0.37
PDE8A O60658 1/20 0.36
HSP90AA1 P07900 4/20 0.35
HSP90AB1 P08238 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29601580 0.81 P2RX7 (0.48) P2RX7HDAC3HDAC4HDAC1HDAC7
SCHEMBL1355050 0.81 P2RX7 (0.48) P2RX7HDAC3HDAC4HDAC1HDAC7
SCHEMBL29444616 0.76 CDK1 (0.51) P2RX7HDAC3HDAC4HDAC1HDAC7
SCHEMBL183244 0.76 CDK1 (0.51) P2RX7HDAC3HDAC4HDAC1HDAC7
SCHEMBL3348188 0.75 P2RX7 (0.48) P2RX7HDAC3HDAC4HDAC1HDAC7
SCHEMBL9563426 0.74 HSP90AB1 (0.50) HDAC4HDAC1HDAC6HSP90AA1HSP90AB1
SCHEMBL9563423 0.74 HSP90AB1 (0.50) HDAC4HDAC1HDAC6HSP90AA1HSP90AB1
SCHEMBL30332411 0.73 P2RX7 (0.49) P2RX7HDAC3HDAC4HDAC1HDAC7
SCHEMBL5158596 0.73 P2RX7 (0.49) P2RX7HDAC3HDAC4HDAC1HDAC7
SCHEMBL11961126 0.73 P2RX7 (0.52) P2RX7HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010059418-A1 SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) 2010-05-27 WO disclosed