SCHEMBL3348188

SCHEMBL3348188

FC(F)Cn1cnc2c(Cl)nc(Cl)nc21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 2/20 0.48
P2RY1 P47900 2/20 0.42
PDE8A O60658 2/20 0.42
HDAC6 Q9UBN7 3/20 0.42
HDAC4 P56524 2/20 0.42
HDAC1 Q13547 2/20 0.42
HDAC3 O15379 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
NPC1 O15118 1/20 0.41
CTSL P07711 1/20 0.41
ELANE P08246 1/20 0.41
CMA1 P23946 1/20 0.41
CTSS P25774 1/20 0.41
CASP1 P29466 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5161430 0.88 P2RX7 (0.46) P2RX7P2RY1HDAC1HDAC2HDAC8
SCHEMBL183219 0.84 HDAC1 (0.50) P2RX7P2RY1HDAC6HDAC4HDAC1
SCHEMBL29444616 0.78 CDK1 (0.51) P2RX7HDAC6HDAC4HDAC1HDAC3
SCHEMBL183244 0.78 CDK1 (0.51) P2RX7HDAC6HDAC4HDAC1HDAC3
SCHEMBL3982080 0.78 FDPS (0.69) P2RX7P2RY1HDAC6HDAC4HDAC1
SCHEMBL5461215 0.77 HDAC6 (0.60) P2RX7HDAC6HDAC4HDAC1HDAC3
SCHEMBL12537292 0.76 P2RX7 (0.47) P2RX7P2RY1HDAC6HDAC4HDAC1
SCHEMBL3347915 0.76 CTSL (0.70) P2RY1HDAC6HDAC4HDAC1HDAC3
SCHEMBL30332411 0.75 P2RX7 (0.49) P2RX7HDAC6HDAC4HDAC1HDAC3
SCHEMBL5158596 0.75 P2RX7 (0.49) P2RX7HDAC6HDAC4HDAC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010059418-A1 SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) 2010-05-27 WO disclosed
WO-2010059418-A1 SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) 2010-05-27 WO disclosed