Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4515598 | 0.85 | ERN1 (0.41) | KMT2AERN1P2RX7CYP2C9CYP1A2 | |
| SCHEMBL13574584 | 0.81 | MAPT (0.36) | ERN1P2RX7CYP1A2KDM4EMAPT | |
| SCHEMBL1569756 | 0.81 | TAAR1 (0.51) | CYP1A2KDM4ETAAR1 | |
| SCHEMBL3415768 | 0.80 | ALDH1A1 (0.43) | KMT2AERN1CYP2C9CYP1A2CYP2D6 | |
| SCHEMBL2996061 | 0.79 | TTR (0.44) | KMT2AERN1P2RX7CYP1A2KDM4E | |
| SCHEMBL15129491 | 0.77 | TAAR1 (0.42) | ERN1P2RX7MAPTTDP1TAAR1 | |
| SCHEMBL20595699 | 0.75 | KDM4E (0.48) | ERN1P2RX7KDM4ETDP1ALDH1A1 | |
| SCHEMBL20652725 | 0.74 | TAAR1 (0.39) | KMT2AERN1CYP2C9KDM4EMAPT | |
| SCHEMBL3411051 | 0.74 | L3MBTL1 (0.41) | CYP1A2CYP2D6KDM4EMAPTTDP1 | |
| SCHEMBL7044311 | 0.73 | HPGD (0.39) | KMT2AERN1P2RX7CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265616-A1 | FURO-AND THIENO[3,2-C]PYRIDINES | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009100282-A1 | FURO-AND THIENO[3,2-C] PYRIDINES | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |