Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417319 | 0.81 | CA12 (0.39) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3412456 | 0.79 | HCRTR1 (0.39) | POLBPIK3CAKMT2A | |
| SCHEMBL1340422 | 0.79 | PTGS1 (0.40) | PIK3CA | |
| SCHEMBL3413481 | 0.76 | HCRTR1 (0.41) | PIK3CA | |
| SCHEMBL2931793 | 0.72 | POLB (0.38) | POLBPIK3CAGAAKMT2A | |
| SCHEMBL2931508 | 0.72 | POLB (0.38) | POLBPIK3CAKMT2A | |
| SCHEMBL1339841 | 0.72 | PTGS1 (0.41) | PIK3CA | |
| SCHEMBL2799729 | 0.72 | POLB (0.38) | POLBPIK3CA | |
| SCHEMBL2926433 | 0.70 | MGLL (0.38) | POLBPIK3CACFD | |
| SCHEMBL3409706 | 0.70 | HCRTR1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |