Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CYP2C18 | P33260 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26983243 | 0.87 | POLB (0.46) | POLBP2RY1CYP2C9GAAMAPT | |
| SCHEMBL27304677 | 0.83 | POLB (0.42) | POLBP2RY1CYP2C9GAAMAPT | |
| SCHEMBL31467450 | 0.83 | CYP2C9 (0.44) | POLBP2RY1CYP2C9GAAMAPT | |
| SCHEMBL9833146 | 0.81 | ALDH1A1 (0.49) | POLBGAAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL6057416 | 0.80 | POLB (0.53) | POLBCYP2C9GAARAB9ANPC1 | |
| SCHEMBL10258998 | 0.78 | POLB (0.47) | POLBP2RY1CYP2C9GAANFKB1 | |
| SCHEMBL27872921 | 0.78 | POLB (0.47) | POLBP2RY1CYP2C9GAAMAPT | |
| SCHEMBL856957 | 0.74 | POLB (0.52) | POLBCYP2C9GAAMAPTSMN1; SMN2 | |
| SCHEMBL3427273 | 0.74 | SMN1; SMN2 (0.40) | RAB9ANPC1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL13495221 | 0.74 | POLB (0.47) | POLBCYP2C9GAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552918-B1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | HOFFMANN LA ROCHE (CH) | 2014-06-11 | — | — | EP | claimed |
| EP-2149551-A1 | N-(indol-3-ylalkyl)-(hetero)arylamid derivatives as modulators of EP2 receptors | Bayer Schering Pharma AG (DE) | 2010-02-03 | — | — | EP | claimed |
| EP-2002834-A1 | Aryl and hetaryl amides as modulators of EP2 receptors | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-12-17 | — | — | EP | claimed |
| EP-2002834-A1 | Aryl and hetaryl amides as modulators of EP2 receptors | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-12-17 | — | — | EP | disclosed |
| EP-1517898-A1 | ARYLCARBONYLPIPERAZINES AND HETEROARYLCARBONYLPIPERAZINES AND THE USE THEREOF FOR TREATING BENIGN AND MALIGNANT TUMOUR DISEASES | Zentaris GmbH (DE) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004002965-A1 | ARYLCARBONYLPIPERAZINES AND HETEROARYLCARBONYLPIPERAZINES AND THE USE THEREOF FOR TREATING BENIGN AND MALIGNANT TUMOUR DISEASES | ZENTARIS GMBH (DE) | 2004-01-08 | — | — | WO | disclosed |
| EP-0269806-B1 | PHENYLPYRAZOLE CARBONIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS PLANT GROWTH REGULATORS AND ANTIDOTES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-02-27 | — | — | EP | disclosed |