Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417583 | 0.81 | POLB (0.50) | KMT2AGAASMN1; SMN2MAPTPOLB | |
| SCHEMBL26983243 | 0.80 | POLB (0.46) | ALDH1A1HPGDGAASMN1; SMN2MAPT | |
| SCHEMBL9831108 | 0.79 | PDE4B (0.42) | ALDH1A1HPGDKMT2AGAATP53 | |
| SCHEMBL13495221 | 0.78 | POLB (0.47) | ALDH1A1HPGDGAASMN1; SMN2MAPT | |
| SCHEMBL9681622 | 0.78 | ALDH1A1 (0.57) | ALDH1A1HPGDKMT2AGAATP53 | |
| SCHEMBL31467450 | 0.76 | CYP2C9 (0.44) | ALDH1A1KMT2AGAASMN1; SMN2MAPT | |
| SCHEMBL2555825 | 0.74 | PDE4D (0.63) | ALDH1A1HPGDTP53ALOX12PDE4D | |
| SCHEMBL6057416 | 0.73 | POLB (0.53) | ALDH1A1GAASMN1; SMN2POLB | |
| SCHEMBL14973580 | 0.73 | HPGD (0.46) | ALDH1A1HPGDKMT2ATP53ALOX12 | |
| SCHEMBL9831007 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KMT2ASMN1; SMN2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |