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Sugi Predict / Compounds / SCHEMBL3417779

SCHEMBL3417779

SCHEMBL3417779

CCOC(=O)c1c(O)n(Cc2ccc(OC)cc2OC)c(=O)n(Cc2ccccc2)c1=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.49
▸ TP53 P04637 2/20 0.47
▸ TDP2 O95551 1/20 0.46
▸ NSD2 O96028 1/20 0.46
▸ PLCG1 P19174 1/20 0.46
▸ PAX8 Q06710 1/20 0.46
▸ TDP1 Q9NUW8 3/20 0.45
▸ EDNRB P24530 2/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ MAPT P10636 3/20 0.45
▸ KDM4E B2RXH2 3/20 0.45
▸ GAA P10253 3/20 0.45
▸ ALDH1A1 P00352 3/20 0.45
▸ FEN1 P39748 1/20 0.44
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ LMNA P02545 1/20 0.44
▸ PKM P14618 1/20 0.44
▸ POLB P06746 1/20 0.43
▸ RXFP1 Q9HBX9 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3418476 0.83 EGLN3 (0.62) TSHRTP53TDP1MAPTKDM4E
SCHEMBL3421301 0.74 RECQL (0.53) TSHRTDP2NSD2PLCG1PAX8
SCHEMBL1642980 0.73 EGLN3 (0.68) TSHRTP53KDM4EGAAALDH1A1
SCHEMBL5331127 0.72 KDM4E (0.58) TSHRTDP2NSD2PLCG1PAX8
SCHEMBL1640761 0.72 EGLN1 (0.43) TSHRTP53TDP1EDNRBMAPT
SCHEMBL1988003 0.71 RAB9A (0.44) TDP1EDNRBMAPTKDM4EGAA
SCHEMBL3419973 0.71 ALOX5 (0.50) TSHRTDP2NSD2PLCG1PAX8
SCHEMBL3423725 0.70 EGLN3 (0.62) TP53EDNRBMAPTALDH1A1FEN1
SCHEMBL12503112 0.69 MAPT (0.48) TSHRTP53TDP1EDNRBMAPT
SCHEMBL3423631 0.69 MEN1 (0.50) TSHRTP53TDP2NSD2PLCG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230227414-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2023-07-20 — — US disclosed
US-11643397-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2023-05-09 — — US disclosed
US-20210347740-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2021-11-11 — — US disclosed
US-20200157055-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2020-05-21 — — US disclosed
US-10336711-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2019-07-02 — — US disclosed
US-20180305323-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2018-10-25 — — US disclosed
US-10035779-B2 Prolyl hydroxylase inhibitors GlaxoSmithKline, LLC (US) 2018-07-31 — — US disclosed
EP-2037922-B9 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2017-08-23 — — EP disclosed
US-20160297772-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2016-10-13 — — US disclosed
US-20150315157-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2015-11-05 — — US disclosed
US-20140336383-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-11-13 — — US disclosed
US-8815884-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2014-08-26 — — US disclosed
US-20140024666-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-01-23 — — US disclosed
EP-2037922-B1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-01-22 — — EP disclosed
US-8557834-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2013-10-15 — — US disclosed
US-20130072487-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2013-03-21 — — US disclosed
US-8324208-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2012-12-04 — — US disclosed
US-20100113444-A1 PROLYL HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION 2010-05-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024666-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-11643397-B2 Prolyl hydroxylase inhibitors HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-20210347740-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-20130072487-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-20100113444-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 TSHR 2718/4885TP53 2864/4885TDP2 2931/4885
US-10336711-B2 Prolyl hydroxylase inhibitors HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-20140336383-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-20160297772-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-20200157055-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-20180305323-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-10035779-B2 Prolyl hydroxylase inhibitors HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-20230227414-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885
US-20150315157-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 TSHR 2722/4885TP53 2953/4885TDP2 3196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.