Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.87 |
| ▸ | DRD3 | P35462 | 4/20 | 0.87 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | HRH2 | P25021 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NCF1 | P14598 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL327835 | 0.93 | DRD2 (1.00) | DRD2DRD3DRD4HRH2HRH3 | |
| Hydrochloric Acid SCHEMBL8576226 | 0.91 | DRD2 (0.96) | DRD2DRD3DRD4HRH2HRH3 | |
| SCHEMBL30407688 | 0.89 | DRD2 (0.72) | DRD2DRD3HTR6CYP2C19HTR3E | |
| SCHEMBL3165674 | 0.86 | DRD2 (0.72) | DRD2DRD3DRD4HRH2HTR6 | |
| Hydrochloric Acid SCHEMBL26690632 | 0.84 | MAPT (0.71) | DRD2DRD3DRD4HRH2HTR6 | |
| SCHEMBL3174809 | 0.84 | DRD2 (0.70) | DRD2DRD3DRD4HRH2HTR6 | |
| SCHEMBL3020451 | 0.84 | DRD2 (0.70) | DRD2DRD3DRD4HRH2HTR6 | |
| SCHEMBL6187316 | 0.84 | DRD2 (0.81) | DRD2DRD3DRD4HRH2HRH3 | |
| SCHEMBL3403612 | 0.83 | ALDH1A1 (0.61) | DRD2DRD3DRD4SMN1; SMN2MAPT | |
| SCHEMBL3400411 | 0.83 | DRD2 (0.59) | DRD2DRD3NCF1HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3561077-B1 | METHODS FOR CELL-PROLIFERATION-RELATED DISORDERS | SERVIER LAB (FR) | 2022-12-21 | — | — | EP | disclosed |
| EP-3561077-A1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | Agios Pharmaceuticals, Inc. (US) | 2019-10-30 | — | — | EP | disclosed |
| EP-2406389-B1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | AGIOS PHARMACEUTICALS INC (US) | 2019-05-08 | — | — | EP | disclosed |
| WO-2012003418-A2 | FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-05 | — | — | WO | disclosed |