Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.81 |
| ▸ | DRD3 | P35462 | 4/20 | 0.81 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.56 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL327835 | 0.90 | DRD2 (1.00) | DRD2DRD3GAAGFERALDH1A1 | |
| Hydrochloric Acid SCHEMBL8576226 | 0.89 | DRD2 (0.96) | DRD2DRD3GAAGFERALDH1A1 | |
| SCHEMBL3418188 | 0.84 | DRD2 (0.87) | DRD2DRD3GAAGFERALDH1A1 | |
| SCHEMBL5457650 | 0.82 | DRD2 (0.77) | DRD2DRD3ALDH1A1POLBLMNA | |
| SCHEMBL2966619 | 0.79 | GAA (0.71) | DRD2DRD3GAAGFERALDH1A1 | |
| SCHEMBL2155668 | 0.79 | GAA (0.71) | DRD2DRD3GAAGFERALDH1A1 | |
| SCHEMBL3399759 | 0.78 | DRD2 (0.71) | DRD2DRD3GAAGFERALDH1A1 | |
| Hydrochloric Acid SCHEMBL5502387 | 0.78 | GAA (0.69) | DRD2DRD3GAAGFERALDH1A1 | |
| SCHEMBL6187320 | 0.78 | HTR6 (0.58) | DRD2DRD3ALDH1A1HTR6KMT2A | |
| SCHEMBL24310707 | 0.78 | DRD2 (0.70) | DRD2DRD3ALDH1A1DRD4HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994862-B1 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | disclosed |
| US-6316450-B1 | PIPERAZINE COMPOUNDS FOR TREATING DEPRESSION AND ANXIETY | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-13 | — | — | US | disclosed |
| EP-0994862-A2 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999002502-A2 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 1999-01-21 | — | — | WO | disclosed |