Sulotroban

Sulotroban

SCHEMBL34187

O=C(O)COc1ccc(CCNS(=O)(=O)c2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 1/20 1.00
TBXAS1 P24557 1/20 1.00
SGMS1 Q86VZ5 11/20 0.68
HTT P42858 1/20 0.64
ALDH1A1 P00352 3/20 0.63
MAPT P10636 1/20 0.63
TDP1 Q9NUW8 2/20 0.60
POLB P06746 1/20 0.59
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11358325 0.92 TBXA2R (0.85) TBXA2RTBXAS1SGMS1HTTALDH1A1
SCHEMBL9127040 0.90 TBXA2R (0.81) TBXA2RTBXAS1SGMS1HTTALDH1A1
SCHEMBL11332922 0.90 TBXA2R (0.81) TBXA2RTBXAS1SGMS1HTTALDH1A1
Sulotroban SCHEMBL11456215 0.89 TBXA2R (0.79) TBXA2RTBXAS1SGMS1HTTALDH1A1
SCHEMBL11348800 0.88 TBXA2R (0.79) TBXA2RTBXAS1SGMS1HTTALDH1A1
SCHEMBL11342321 0.88 TBXA2R (0.79) TBXA2RTBXAS1SGMS1HTTALDH1A1
SCHEMBL8840163 0.88 TBXA2R (0.79) TBXA2RTBXAS1SGMS1HTTALDH1A1
Sulotroban SCHEMBL9585833 0.88 TBXA2R (0.79) TBXA2RTBXAS1SGMS1HTTALDH1A1
SCHEMBL11371899 0.88 TBXA2R (0.79) TBXA2RTBXAS1SGMS1HTTALDH1A1
SCHEMBL9512082 0.87 TBXA2R (0.76) TBXA2RTBXAS1SGMS1HTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1340 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260041336-A1 PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK NEW YORK UNIVERSITY (US) 2026-02-12 US claimed
US-20250144079-A1 METHODS OF INHIBITING TUMOR METASTASIS VANDERBILT UNIVERSITY 2025-05-08 US claimed
US-20240041839-A1 METHODS OF INHIBITING TUMOR METASTASIS VANDERBILT UNIVERSITY 2024-02-08 US claimed
US-20230090578-A1 METHODS OF INHIBITING TUMOR METASTASIS VANDERBILT UNIVERSITY 2023-03-23 US claimed
US-11136342-B2 Carbonate prodrugs and methods of using the same ACORDA THERAPEUTICS, INC. (US) 2021-10-05 US claimed
US-20200405694-A1 METHODS OF INHIBITING TUMOR METASTASIS VANDERBILT UNIVERSITY 2020-12-31 US claimed
EP-3716973-A1 METHODS OF INHIBITING TUMOR METASTASIS Vanderbilt University (US) 2020-10-07 EP claimed
US-20200157126-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME ACORDA THERAPEUTICS, INC. 2020-05-21 US claimed
WO-2016102352-A1 TXA2 INHIBITOR AS STIMULATOR OR INDUCER OF MHC CLASS I CROSS-PRESENTATION INSTITUT PASTEUR (FR) 2016-06-30 WO claimed
EP-3037106-A1 TXA2 inhibitor as stimulator or inducer of MHC Class I cross-presentation INSTITUT PASTEUR (FR) 2016-06-29 EP claimed
WO-1996017606-A1 USE OF INFLAMMATORY MODULATORS IN THE TREATMENT OF CHRONIC OR RECALCITRANT SKIN DAMAGE BRISTOL-MYERS SQUIBB COMPANY (US) 1996-06-13 WO claimed
US-5324749-A Anticholesterol, antiischemic agents BOEHRINGER MANNHEIM GMBH (DE) 1994-06-28 US claimed
EP-0558062-A2 Phenoxyacetic acid derivatives and pharmaceutical compositions containing them ONO PHARMACEUTICAL CO., LTD. (JP) 1993-09-01 EP claimed
EP-0523086-A1 PHARMACEUTICAL AQUEOUS SOLUTION OF 4- 2-(BENZOLSULPHONYLAMINO)-ETHYL]-PHENOXYACETIC ACID Roche Diagnostics GmbH (DE) 1993-01-20 EP claimed
EP-0268581-B1 PROSTACYCLINES, THEIR ANALOGUES OR PROSTAGLANDINES AND THROMBOXANE ANTAGONISTS FOR THE TREATMENT OF THROMBOTIC AND THROMBO-EMBOLIC ILLNESSES SCHERING AKTIENGESELLSCHAFT (DE) 1992-04-08 EP claimed
WO-1991015202-A1 PHARMACEUTICAL AQUEOUS SOLUTION OF 4-[2-(BENZOLSULPHONYLAMINO)-ETHYL]-PHENOXYACETIC ACID BOEHRINGER MANNHEIM GMBH (DE) 1991-10-17 WO claimed
EP-0449764-A2 A method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor and/or thromboxane receptor antagonist CIBA-GEIGY AG (CH) 1991-10-02 EP claimed
US-5021448-A Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist CIBA-GEIGY CORPORATION (US) 1991-06-04 US claimed
EP-0300675-A2 Method for the improvement of cyclosporine therapy MERCK FROSST CANADA INC. (CA) 1989-01-25 EP claimed
US-4258058-A Phenoxyalkylcarboxylic acid compounds and thrombocyte-aggregation inhibition BOEHRINGER MANNHEIM GMBH (DE) 1981-03-24 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250144079-A1 METHODS OF INHIBITING TUMOR METASTASIS TBXA2R, ADORA2B, ADORA2A TBXA2R 1/4885TBXAS1 4/4885SGMS1 3147/4885
US-20200157126-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME CA6, CA7, CA4 TBXA2R 1641/4885TBXAS1 1697/4885SGMS1 969/4885
US-20240041839-A1 METHODS OF INHIBITING TUMOR METASTASIS TBXA2R, ADORA2B, ADORA2A TBXA2R 1/4885TBXAS1 4/4885SGMS1 3147/4885
US-20200405694-A1 METHODS OF INHIBITING TUMOR METASTASIS TBXA2R, ADORA2B, ADORA2A TBXA2R 1/4885TBXAS1 4/4885SGMS1 3147/4885
US-11136342-B2 Carbonate prodrugs and methods of using the same CA6, CA7, CA4 TBXA2R 1641/4885TBXAS1 1697/4885SGMS1 969/4885
US-20230090578-A1 METHODS OF INHIBITING TUMOR METASTASIS TBXA2R, ADORA2B, ADORA2A TBXA2R 1/4885TBXAS1 4/4885SGMS1 3147/4885
US-20260041336-A1 PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK EPB41L2, MYLK2, RABL3 TBXA2R 2982/4885TBXAS1 220/4885SGMS1 2827/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.