Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 19/20 | 0.74 |
| ▸ | CTSB | P07858 | 17/20 | 0.74 |
| ▸ | CTSL | P07711 | 16/20 | 0.74 |
| ▸ | CTSK | P43235 | 13/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3420805 | 0.92 | CTSS (0.88) | CTSSCTSBCTSLCTSK | |
| SCHEMBL3418926 | 0.86 | CTSL (0.69) | CTSSCTSBCTSLCTSK | |
| SCHEMBL7801025 | 0.84 | CTSS (1.00) | CTSSCTSBCTSLCTSK | |
| SCHEMBL3478436 | 0.83 | CTSS (0.84) | CTSSCTSBCTSLCTSK | |
| SCHEMBL3476615 | 0.82 | CTSS (1.00) | CTSSCTSBCTSLCTSK | |
| SCHEMBL1273060 | 0.81 | CTSS (0.78) | CTSSCTSBCTSLCTSK | |
| SCHEMBL1273059 | 0.81 | CTSS (0.78) | CTSSCTSBCTSLCTSK | |
| SCHEMBL1272508 | 0.80 | CTSS (0.80) | CTSSCTSBCTSLCTSK | |
| SCHEMBL1271541 | 0.80 | CTSS (0.80) | CTSSCTSBCTSLCTSK | |
| SCHEMBL7806217 | 0.80 | CTSS (0.82) | CTSSCTSBCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101053-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | MERCK CANADA INC. (CA) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101053-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | CTSL, CTSS, CTSZ | CTSS 2/4885CTSB 5/4885CTSL 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.