Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.43 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL343423 | 0.88 | AADAT (0.45) | AADATTSHRL3MBTL1GFERTMEM97 | |
| SCHEMBL342015 | 0.86 | TRPV1 (0.38) | TSHRNPSR1KDM4E | |
| SCHEMBL341365 | 0.84 | AADAT (0.44) | AADATTSHRL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL341368 | 0.84 | AADAT (0.44) | AADATTSHRL3MBTL1GFERTMEM97 | |
| SCHEMBL14144526 | 0.83 | GRM5 (0.41) | — | |
| SCHEMBL341914 | 0.82 | AADAT (0.45) | AADATTSHRL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL341458 | 0.82 | GFER (0.47) | AADATTSHRL3MBTL1GFERTMEM97 | |
| SCHEMBL342287 | 0.79 | GFER (0.47) | AADATTSHRL3MBTL1GFERTMEM97 | |
| SCHEMBL342123 | 0.79 | ALDH1A1 (0.45) | AADATTSHRL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL342735 | 0.79 | AADAT (0.42) | AADATTSHRL3MBTL1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-8063218-B2 | Imidazopyridine inhibitors of IAP | GENENTECH, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063218-B2 | Imidazopyridine inhibitors of IAP | GENENTECH, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063218-B2 | Imidazopyridine inhibitors of IAP | GENENTECH, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH INC. (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH INC. (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH INC. (US) | 2010-05-27 | — | — | US | disclosed |
| EP-2125809-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | Genentech, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079735-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | AADAT 4260/4885TSHR 3064/4885L3MBTL1 848/4885 |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | AADAT 4260/4885TSHR 3064/4885L3MBTL1 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.