Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.44 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.42 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.42 |
| ▸ | PREP | P48147 | 3/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342735 | 0.90 | AADAT (0.42) | AADATPREPTMEM97SIGMAR1TSHR | |
| SCHEMBL341368 | 0.90 | AADAT (0.44) | AADATPREPTMEM97SIGMAR1TSHR | |
| SCHEMBL342833 | 0.89 | AADAT (0.42) | AADATPREPTMEM97SIGMAR1TSHR | |
| SCHEMBL341914 | 0.89 | AADAT (0.45) | AADATPREPTMEM97SIGMAR1TSHR | |
| SCHEMBL342123 | 0.88 | ALDH1A1 (0.45) | AADATPREPTMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL342099 | 0.88 | AADAT (0.41) | AADATPREPTMEM97SIGMAR1TSHR | |
| SCHEMBL341458 | 0.86 | GFER (0.47) | AADATPREPTMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL342144 | 0.85 | ALDH1A3 (0.50) | ALDH1A3ALDH1A2ALDH1A1TSHR | |
| SCHEMBL341933 | 0.84 | AADAT (0.44) | AADATPREPTMEM97SIGMAR1TSHR | |
| SCHEMBL14144746 | 0.82 | ALDH1A3 (0.47) | ALDH1A3ALDH1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-8063218-B2 | Imidazopyridine inhibitors of IAP | GENENTECH, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063218-B2 | Imidazopyridine inhibitors of IAP | GENENTECH, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH INC. (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH INC. (US) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | AADAT 4260/4885ALDH1A3 4275/4885ALDH1A2 4334/4885 |
| US-20100130539-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | AADAT 4260/4885ALDH1A3 4275/4885ALDH1A2 4334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.