Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 15/20 | 0.81 |
| ▸ | CTSS | P25774 | 14/20 | 0.81 |
| ▸ | CTSB | P07858 | 13/20 | 0.81 |
| ▸ | CTSK | P43235 | 11/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805779 | 0.90 | CTSL (1.00) | CTSLCTSSCTSBCTSK | |
| SCHEMBL3418942 | 0.89 | CTSS (0.83) | CTSLCTSSCTSBCTSK | |
| SCHEMBL3417549 | 0.88 | CTSS (0.82) | CTSLCTSSCTSBCTSK | |
| SCHEMBL3417576 | 0.84 | CTSS (0.83) | CTSLCTSSCTSBCTSK | |
| SCHEMBL3420890 | 0.83 | CTSL (0.63) | CTSLCTSSCTSBCTSK | |
| SCHEMBL3417590 | 0.82 | CTSL (0.84) | CTSLCTSSCTSBCTSK | |
| SCHEMBL3476615 | 0.82 | CTSS (1.00) | CTSLCTSSCTSBCTSK | |
| SCHEMBL3417965 | 0.81 | CTSS (0.84) | CTSLCTSSCTSBCTSK | |
| SCHEMBL3418948 | 0.81 | CTSL (0.84) | CTSLCTSSCTSBCTSK | |
| SCHEMBL3419363 | 0.81 | CTSS (0.68) | CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101053-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | MERCK CANADA INC. (CA) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101053-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | CTSL, CTSS, CTSZ | CTSL 1/4885CTSS 2/4885CTSB 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.