⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8749379 | 0.72 | PRKCA (0.46) | — | |
| SCHEMBL5864513 | 0.62 | — | — | |
| SCHEMBL30773540 | 0.62 | — | — | |
| SCHEMBL11221232 | 0.60 | LSS (0.40) | — | |
| SCHEMBL8187222 | 0.60 | LSS (0.40) | — | |
| SCHEMBL5084457 | 0.60 | LMNA (0.33) | — | |
| SCHEMBL1697969 | 0.60 | — | — | |
| SCHEMBL2439872 | 0.56 | — | — | |
| SCHEMBL5075179 | 0.56 | — | — | |
| SCHEMBL27832626 | 0.56 | ALOX5 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399512-B2 | Biocompatible biodegradable fumagillin analog conjugates | MERSANA THERAPEUTICS, INC. (US) | 2013-03-19 | — | — | US | claimed |
| EP-2217283-A2 | BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES | Mersana Therapeutics, Inc. (US) | 2010-08-18 | — | — | EP | claimed |
| US-20090148396-A1 | BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES | MERSANA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | claimed |
| WO-2009073445-A2 | BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES | MERSANA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | WO | claimed |