Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MARS2 | Q96GW9 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.31 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.31 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3419152 | 1.00 | LMNA (0.39) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| SCHEMBL3419233 | 1.00 | LMNA (0.39) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| SCHEMBL3421254 | 0.84 | LMNA (0.38) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| SCHEMBL2295299 | 0.84 | PAX8 (0.41) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| SCHEMBL3415637 | 0.84 | LMNA (0.38) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| SCHEMBL3414706 | 0.84 | LMNA (0.38) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| SCHEMBL1303718 | 0.84 | PAX8 (0.41) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| SCHEMBL5326303 | 0.84 | PAX8 (0.41) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| SCHEMBL3414678 | 0.84 | LMNA (0.38) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| SCHEMBL3415356 | 0.84 | LMNA (0.38) | LMNAL3MBTL1PDE4ATDP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173166-A1 | INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME | Children's Hospital & Research Center at Oakland (US) | 2010-04-14 | — | — | EP | claimed |
| WO-2009006591-A1 | INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME | CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND (US) | 2009-01-08 | — | — | WO | claimed |
| US-20090012043-A1 | INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-01-08 | — | — | US | claimed |
| US-8999954-B2 | Inhibitors of polysialic acid de-N-acetylase and methods for using the same | Childern's Hospital & Research Center at Oakland (US) | 2015-04-07 | — | — | US | disclosed |
| EP-2173166-A1 | INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME | Children's Hospital & Research Center at Oakland (US) | 2010-04-14 | — | — | EP | disclosed |
| US-20090012043-A1 | INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-01-08 | — | — | US | disclosed |
| WO-2009006591-A1 | INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME | CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012043-A1 | INHIBITORS OF POLYSIALIC ACID DE-N-ACETYLASE AND METHODS FOR USING THE SAME | ENGASE, NANS, NEU1 | LMNA 1441/4885L3MBTL1 4500/4885PDE4A 2948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.