Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 20/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3102591 | 0.69 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL3102603 | 0.69 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL533858 | 0.68 | REN (0.46) | RENKCNH2CYP3A4 | |
| SCHEMBL7004831 | 0.66 | REN (0.42) | RENKCNH2CYP3A4 | |
| SCHEMBL533971 | 0.65 | DRD2 (0.59) | RENKCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL22616883 | 0.63 | DRD2 (0.58) | RENKCNH2CYP3A4 | |
| SCHEMBL6966294 | 0.63 | GHSR (0.43) | — | |
| SCHEMBL3107459 | 0.62 | DRD2 (0.47) | RENKCNH2CYP3A4 | |
| SCHEMBL651950 | 0.62 | DRD2 (0.41) | RENKCNH2 | |
| SCHEMBL5169982 | 0.62 | CYP2C19 (0.44) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229363-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009070869-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-06-11 | — | — | WO | disclosed |