Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.55 |
| ▸ | TUBB | P07437 | 3/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.55 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.55 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.55 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.55 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421287 | 0.91 | IDO1 (0.46) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3418903 | 0.86 | HTR2C (0.49) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3422165 | 0.86 | IDO1 (0.56) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3418785 | 0.85 | HTR2C (0.64) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3416726 | 0.83 | TUBB4A (0.49) | IDO1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3546875 | 0.80 | HTR1A (0.55) | HTR2CSLC6A4HTR1ASLC6A2SLC6A3 | |
| SCHEMBL2781047 | 0.79 | HTR2C (0.62) | IDO1HTR2CADRB2SLC6A4OPRM1 | |
| SCHEMBL3420383 | 0.79 | HTR2A (0.46) | IDO1HTR2CADRB2SLC6A4OPRM1 | |
| SCHEMBL3416202 | 0.79 | HTR2C (0.46) | IDO1HTR2CADRB2SLC6A4HTR1A | |
| Hydrochloric Acid SCHEMBL893002 | 0.78 | HTR2C (0.63) | IDO1HTR2CADRB2SLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678800-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives for use in the treatment of affective disorders, pain, ADHD and stress urinary incontinence | H. LUNDBECK A/S (DK) | 2010-03-16 | — | — | US | claimed |
| EP-1771415-B1 | 2- (1H-INDOLYLSULFANYL) -ARYL AMINE DERIVATIVES FOR USE IN THE TREATMENT OF AFFECTIVE DISORDERS, PAIN, ADHD AND STRESS URINARY INCONTINENCE | LUNDBECK & CO AS H (DK) | 2009-01-07 | — | — | EP | claimed |
| US-20080027074-A1 | 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence | H. LUNDBECK A/S (DK) | 2008-01-31 | — | — | US | claimed |
| US-7678800-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives for use in the treatment of affective disorders, pain, ADHD and stress urinary incontinence | H. LUNDBECK A/S (DK) | 2010-03-16 | — | — | US | disclosed |
| EP-1771415-B1 | 2- (1H-INDOLYLSULFANYL) -ARYL AMINE DERIVATIVES FOR USE IN THE TREATMENT OF AFFECTIVE DISORDERS, PAIN, ADHD AND STRESS URINARY INCONTINENCE | LUNDBECK & CO AS H (DK) | 2009-01-07 | — | — | EP | disclosed |
| US-20080027074-A1 | 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence | H. LUNDBECK A/S (DK) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027074-A1 | 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence | SLC6A2, HTR2C, SLC6A3 | IDO1 50/4885TUBB4A 2065/4885TUBB 1584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.