Sugi Predict

Sugi Predict / Compounds / SCHEMBL3422052

SCHEMBL3422052

SCHEMBL3422052

COc1ccccc1CN1C(=O)CC(=O)N(Cc2ccccc2OC)C1=O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 2/20 0.58
▸ HSD17B10 Q99714 1/20 0.58
▸ GAA P10253 2/20 0.54
▸ KDM4E B2RXH2 2/20 0.54
▸ RECQL P46063 2/20 0.54
▸ MEN1 O00255 4/20 0.51
▸ KMT2A Q03164 4/20 0.51
▸ CYP1A2 P05177 1/20 0.51
▸ CYP3A4 P08684 1/20 0.51
▸ TSHR P16473 1/20 0.51
▸ CYP2C19 P33261 1/20 0.51
▸ LMNA P02545 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ POLB P06746 1/20 0.45
▸ MAPT P10636 1/20 0.45
▸ BLM P54132 1/20 0.45
▸ SIGMAR1 Q99720 1/20 0.45
▸ HSP90AA1 P07900 1/20 0.44
▸ HSP90B1 P14625 1/20 0.44
▸ TRAP1 Q12931 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15419130 0.82 MEN1 (0.58) USP2HSD17B10GAAKDM4ERECQL
SCHEMBL29585298 0.78 PTGS1 (0.61) USP2HSD17B10GAAKDM4ERECQL
SCHEMBL7218634 0.78 PTGS1 (0.61) USP2HSD17B10GAAKDM4ERECQL
SCHEMBL18669183 0.77 GAA (0.78) USP2HSD17B10GAAKDM4ERECQL
SCHEMBL20339364 0.75 GSK3A (0.59) USP2HSD17B10GAAKDM4ERECQL
SCHEMBL8134728 0.75 USP2 (0.52) USP2HSD17B10GAAKDM4ERECQL
SCHEMBL3415753 0.75 MEN1 (0.56) USP2HSD17B10GAAKDM4ERECQL
SCHEMBL7209206 0.74 ACHE (0.60) USP2HSD17B10MEN1KMT2ASIGMAR1
SCHEMBL10341830 0.73 USP2 (0.57) USP2HSD17B10GAAKDM4ERECQL
SCHEMBL7484195 0.72 ACHE (0.68) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230227414-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2023-07-20 — — US disclosed
US-11643397-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2023-05-09 — — US disclosed
US-20210347740-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2021-11-11 — — US disclosed
US-20200157055-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2020-05-21 — — US disclosed
US-10336711-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2019-07-02 — — US disclosed
US-20180305323-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2018-10-25 — — US disclosed
EP-2037922-B9 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2017-08-23 — — EP disclosed
US-20150315157-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2015-11-05 — — US disclosed
US-20140336383-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-11-13 — — US disclosed
US-8815884-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2014-08-26 — — US disclosed
US-20140024666-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-01-23 — — US disclosed
EP-2037922-B1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-01-22 — — EP disclosed
US-8557834-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2013-10-15 — — US disclosed
US-20130072487-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2013-03-21 — — US disclosed
US-8324208-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2012-12-04 — — US disclosed
US-20100113444-A1 PROLYL HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION 2010-05-06 — — US disclosed
EP-2037922-A2 PROLYL HYDROXYLASE INHIBITORS SmithKline Beecham Corporation (US) 2009-03-25 — — EP disclosed
WO-2007150011-A2 PROLYL HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2007-12-27 — — WO disclosed
US-6114546-A Aminomethylene derivatives and ultraviolet absorbent comprising thereof CHEMIPRO KASEI KAISHA, LIMITED (JP) 2000-09-05 — — US disclosed
EP-0950655-A1 AMINOMETHYLENE DERIVATIVES AND ULTRAVIOLET ABSORBER COMPRISING THE SAME CHEMIPRO KASEI KAISHA, LIMITED (JP) 1999-10-20 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024666-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885
US-11643397-B2 Prolyl hydroxylase inhibitors HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885
US-20210347740-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885
US-20130072487-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885
US-20100113444-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 USP2 1773/4885HSD17B10 573/4885GAA 170/4885
US-10336711-B2 Prolyl hydroxylase inhibitors HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885
US-20140336383-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885
US-20200157055-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885
US-20180305323-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885
US-20230227414-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885
US-20150315157-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 USP2 1676/4885HSD17B10 634/4885GAA 224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.