SCHEMBL3422141

SCHEMBL3422141

C=C(Cc1ccc2c(CC(=C)C(=O)O)cccc2c1)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.46
AKR1B1 P15121 1/20 0.46
SLC22A12 Q96S37 1/20 0.39
ATM Q13315 1/20 0.38
KMT2A Q03164 4/20 0.36
MEN1 O00255 3/20 0.36
KDM4E B2RXH2 1/20 0.36
LMNA P02545 1/20 0.36
HPGD P15428 1/20 0.36
PTGER4 P35408 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
SOX18 P35713 1/20 0.36
TBXAS1 P24557 1/20 0.35
CYP1A2 P05177 1/20 0.35
ALOX5 P09917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3424249 0.88 TDP1 (0.46) TDP1AKR1B1SLC22A12ATMKMT2A
SCHEMBL3423716 0.83 TDP1 (0.44) TDP1AKR1B1ATMKMT2AMEN1
SCHEMBL819647 0.82 TDP1 (0.68) TDP1ATMKMT2AMEN1KDM4E
SCHEMBL2243225 0.81 TDP1 (0.49) TDP1ATMKMT2AMEN1KDM4E
SCHEMBL30496795 0.81 TDP1 (0.66) TDP1AKR1B1SLC22A12KMT2AMEN1
SCHEMBL7445814 0.79 ALOX5 (0.53) AKR1B1KMT2AMEN1CYP1A2ALOX5
SCHEMBL3423766 0.78 TDP1 (0.50) TDP1AKR1B1ATMKMT2AMEN1
SCHEMBL3421625 0.78 AKR1C3 (0.49) TDP1AKR1B1KMT2AMEN1KDM4E
SCHEMBL3422957 0.77 TDP1 (0.40) TDP1ATMKMT2AMEN1KDM4E
SCHEMBL26180948 0.77 TDP1 (0.56) TDP1AKR1B1ATMKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007110387-A1 PHOTO-CURABLE RESINS AND RESIN COMPOSITIONS WITH VERY HIGH REFRACTIVE INDICES FOR APPLICATION IN PLASIC OPTICS SEEREAL TECHNOLOGIES S.A. (DE) 2007-10-04 WO claimed
EP-1840652-A1 Photo-curable resins and resin compositions with very high refractive indices for application in plastic optics SeeReal Technologies S.A. (LU) 2007-10-03 EP claimed
EP-0644232-B1 Free radical cured rubber GOODYEAR TIRE & RUBBER (US) 1997-03-05 EP claimed
EP-0644232-A1 Free radical cured rubber THE GOODYEAR TIRE & RUBBER COMPANY (US) 1995-03-22 EP claimed
US-5310811-A Abrasion resistance THE GOODYEAR TIRE & RUBBER COMPANY (US) 1994-05-10 US claimed
US-8080603-B2 Low hysteresis rubber elastomer MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2011-12-20 US disclosed
US-20100056686-A1 LOW HYSTERESIS RUBBER ELASTOMER SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2010-03-04 US disclosed
US-20100012241-A1 CUSHION GUM MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2010-01-21 US disclosed
EP-2114696-A1 LOW HYSTERESIS RUBBER ELASTOMER Societe de Technologie Michelin (FR) 2009-11-11 EP disclosed
WO-2008079726-A1 CUSHION GUM SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2008-07-03 WO disclosed
WO-2008079107-A1 LOW HYSTERESIS RUBBER ELASTOMER SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2008-07-03 WO disclosed
WO-2007110387-A1 PHOTO-CURABLE RESINS AND RESIN COMPOSITIONS WITH VERY HIGH REFRACTIVE INDICES FOR APPLICATION IN PLASIC OPTICS SEEREAL TECHNOLOGIES S.A. (DE) 2007-10-04 WO disclosed
EP-1840652-A1 Photo-curable resins and resin compositions with very high refractive indices for application in plastic optics SeeReal Technologies S.A. (LU) 2007-10-03 EP disclosed
EP-0644232-B1 Free radical cured rubber GOODYEAR TIRE & RUBBER (US) 1997-03-05 EP disclosed
EP-0644232-A1 Free radical cured rubber THE GOODYEAR TIRE & RUBBER COMPANY (US) 1995-03-22 EP disclosed
US-5310811-A Abrasion resistance THE GOODYEAR TIRE & RUBBER COMPANY (US) 1994-05-10 US disclosed