Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.54 |
| ▸ | HTR1A | P08908 | 7/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421798 | 0.85 | HTR2C (0.51) | HTR2CHTR1ASLC6A2SLC6A4ADRB2 | |
| SCHEMBL3418989 | 0.82 | SLC6A4 (0.44) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3419770 | 0.82 | HTR2C (0.44) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3418826 | 0.82 | HTR2C (0.41) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3418785 | 0.78 | HTR2C (0.64) | HTR2CHTR1ASLC6A2SLC6A4ADRB2 | |
| SCHEMBL3422135 | 0.77 | HTR3A (0.68) | HTR1AHTR6HTR3A | |
| SCHEMBL3416726 | 0.76 | TUBB4A (0.49) | HTR2CADRB2IDO1HTR6TUBB4A | |
| SCHEMBL3418567 | 0.76 | HTR2C (0.49) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL330081 | 0.72 | HTR2C (1.00) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29891667 | 0.72 | HTR2C (1.00) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678800-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives for use in the treatment of affective disorders, pain, ADHD and stress urinary incontinence | H. LUNDBECK A/S (DK) | 2010-03-16 | — | — | US | claimed |
| EP-1771415-B1 | 2- (1H-INDOLYLSULFANYL) -ARYL AMINE DERIVATIVES FOR USE IN THE TREATMENT OF AFFECTIVE DISORDERS, PAIN, ADHD AND STRESS URINARY INCONTINENCE | LUNDBECK & CO AS H (DK) | 2009-01-07 | — | — | EP | claimed |
| US-20080027074-A1 | 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence | H. LUNDBECK A/S (DK) | 2008-01-31 | — | — | US | claimed |
| US-7678800-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives for use in the treatment of affective disorders, pain, ADHD and stress urinary incontinence | H. LUNDBECK A/S (DK) | 2010-03-16 | — | — | US | disclosed |
| EP-1771415-B1 | 2- (1H-INDOLYLSULFANYL) -ARYL AMINE DERIVATIVES FOR USE IN THE TREATMENT OF AFFECTIVE DISORDERS, PAIN, ADHD AND STRESS URINARY INCONTINENCE | LUNDBECK & CO AS H (DK) | 2009-01-07 | — | — | EP | disclosed |
| US-20080027074-A1 | 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence | H. LUNDBECK A/S (DK) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027074-A1 | 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence | SLC6A2, HTR2C, SLC6A3 | HTR2C 2/4885HTR1A 22/4885SLC6A2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.